PMID- 20926836
OWN - NLM
STAT- MEDLINE
DCOM- 20101220
LR  - 20211020
IS  - 1942-5546 (Electronic)
IS  - 0025-6196 (Print)
IS  - 0025-6196 (Linking)
VI  - 85
IP  - 11
DP  - 2010 Nov
TI  - Human herpesvirus 6 infection as a trigger of multiple sclerosis.
PG  - 1023-30
LID - 10.4065/mcp.2010.0350 [doi]
AB  - We systematically reviewed the existing evidence to determine whether a 
      relationship exists between infection with human herpesvirus 6 (HHV-6) and 
      multiple sclerosis (MS) and, if so, to define the strength of that relationship. 
      The following terms were used in searches of the Entrez-PubMed database 
      (1966-2009): human herpes virus 6, HHV 6, demyelination, multiple sclerosis, 
      pathogenesis, diagnosis, serology, cerebrospinal fluid, IgG antibodies, IgM 
      antibodies, PCR, and lymphoproliferative techniques. Study quality was assessed 
      using the criteria proposed by Moore and Wolfson and by the classification 
      criteria used by the Canadian Task Force on the Periodic Health Examination. 
      Studies were categorized both by experimental technique and by quality (high [A], 
      intermediate [B], and low [C]) as determined by the Moore and Wolfson criteria. 
      Overall, 25 (41%) of 61 studies, 15 (60%) of which were classified as A quality, 
      reached a statistically significant result. According to the Canadian Task Force 
      classification, all studies were categorized as evidence of quality II-1. 
      Limitations of the available experimental techniques and perspectives for future 
      research are discussed. The current review supports the need for further, 
      objective, evidence-based examination of the relationship between HHV-6 infection 
      and multiple sclerosis.
FAU - Voumvourakis, Konstantine I
AU  - Voumvourakis KI
AD  - 2nd Department of Neurology, Attikon University Hospital, University of Athens 
      Medical School, Athens, Greece. cvoumvou@otenet.gr
FAU - Kitsos, Dimitrios K
AU  - Kitsos DK
FAU - Tsiodras, Sotirios
AU  - Tsiodras S
FAU - Petrikkos, George
AU  - Petrikkos G
FAU - Stamboulis, Eleftherios
AU  - Stamboulis E
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20101006
PL  - England
TA  - Mayo Clin Proc
JT  - Mayo Clinic proceedings
JID - 0405543
RN  - 0 (Biomarkers)
SB  - IM
MH  - Biomarkers/blood/cerebrospinal fluid
MH  - Herpesvirus 6, Human/immunology/isolation & purification/*physiology
MH  - Humans
MH  - Multiple Sclerosis/blood/cerebrospinal fluid/immunology/*virology
MH  - Roseolovirus Infections/blood/cerebrospinal fluid/immunology/*virology
PMC - PMC2966366
EDAT- 2010/10/12 06:00
MHDA- 2010/12/21 06:00
PMCR- 2011/05/01
CRDT- 2010/10/08 06:00
PHST- 2010/10/08 06:00 [entrez]
PHST- 2010/10/12 06:00 [pubmed]
PHST- 2010/12/21 06:00 [medline]
PHST- 2011/05/01 00:00 [pmc-release]
AID - S0025-6196(11)60093-1 [pii]
AID - 10.4065/mcp.2010.0350 [doi]
PST - ppublish
SO  - Mayo Clin Proc. 2010 Nov;85(11):1023-30. doi: 10.4065/mcp.2010.0350. Epub 2010 
      Oct 6.