PMID- 20927682
OWN - NLM
STAT- MEDLINE
DCOM- 20101129
LR  - 20180802
IS  - 1424-3997 (Electronic)
IS  - 0036-7672 (Linking)
VI  - 140
DP  - 2010
TI  - Meniere's disease and the use of proton pump inhibitors.
PG  - w13104
LID - 10.4414/smw.2010.13104 [doi]
AB  - PRINCIPLES: On the basis of previous observations we examined the possibility of 
      a favourable effect of proton pump inhibitors (PPI) on Meniere's disease (MD). A 
      preliminary step was made by retrospectively analysing the number of menieric 
      crisis in group of patients suffering from MD and using PPI for other reasons as 
      compared to a group of menieric subjects who had never used PPI. METHODS: Between 
      January 2001 and December 2006, 42 patients affected by MD were examined in the 
      tertiary referral centre at the University Hospital of Bologna, Italy and in the 
      private office of an ENT specialist in Cassino, Italy. Within the study group, 18 
      patients had used PPI for various reasons for at least 12 consecutive months, 
      whilst 24 patients had never been prescribed them. We recorded the number of 
      menieric crises reported in the observation period. The mean follow-up period was 
      21.9 months. Statistical analysis was performed by means of the x2 test and 
      significance was defined when p<0.05. RESULTS: Most of MD patients (72%) using 
      PPI suffered less than one episode of menieric crisis/year. On the other hand 
      patients who had never used a PPI, experienced considerably more episodes only 
      16.7% having less than one crisis per year. This difference was statistically 
      significant (p<0, 001). CONCLUSIONS: Even taking the limitations of this 
      retrospective study into account the reported data nevertheless strongly suggest 
      a possible role for proton pumps in the pathogenesis of MD. This could lead to 
      interesting developments and contribute to a better definition of MD and the 
      therapeutic possibilities.
FAU - Pirodda, Antonio
AU  - Pirodda A
AD  - Department of Specialist Surgical and Anesthesiological Sciences, University of 
      Bologna, Italy.
FAU - Modugno, Giovanni Carlo
AU  - Modugno GC
FAU - Manzari, Leonardo
AU  - Manzari L
FAU - Raimondi, Maria Chiara
AU  - Raimondi MC
FAU - Brandolini, Cristina
AU  - Brandolini C
FAU - Ferri, Gian Gaetano
AU  - Ferri GG
FAU - Borghi, Claudio
AU  - Borghi C
LA  - eng
PT  - Journal Article
DEP - 20101007
PL  - Switzerland
TA  - Swiss Med Wkly
JT  - Swiss medical weekly
JID - 100970884
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - Humans
MH  - Male
MH  - Meniere Disease/*drug therapy
MH  - Middle Aged
MH  - Proton Pump Inhibitors/*therapeutic use
MH  - Retrospective Studies
MH  - Treatment Outcome
EDAT- 2010/10/12 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/10/08 06:00
PHST- 2010/10/08 06:00 [entrez]
PHST- 2010/10/12 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - smw-13104 [pii]
AID - 10.4414/smw.2010.13104 [doi]
PST - epublish
SO  - Swiss Med Wkly. 2010 Oct 7;140:w13104. doi: 10.4414/smw.2010.13104. eCollection 
      2010.