PMID- 20929505
OWN - NLM
STAT- MEDLINE
DCOM- 20110203
LR  - 20221207
IS  - 1753-0407 (Electronic)
IS  - 1753-0407 (Linking)
VI  - 1
IP  - 2
DP  - 2009 Jun
TI  - Effects of systolic and diastolic blood pressures on incident coronary heart 
      disease and all-cause death in Chinese women with Type 2 diabetes: the Hong Kong 
      Diabetes Registry.
PG  - 90-8
LID - 10.1111/j.1753-0407.2009.00023.x [doi]
AB  - BACKGROUND: Elevated blood pressure (BP) is an important risk factor for the 
      development of coronary heart disease (CHD), although the threshold above which 
      the risk increases has not been clearly defined. The aim of the present study was 
      to examine the full-range association between BP and CHD. METHODS: A prospective 
      cohort of 3861 Chinese women with Type 2 diabetes mellitus (T2DM) was followed 
      for a median of 5.61 years. Restricted cubic spline analysis was used to examine 
      the relationship between BP and CHD. RESULTS: Subjects who developed CHD were 
      older, more likely to be smokers, had a significantly longer duration of 
      diabetes, higher systolic BP (SBP), glycated hemoglobin, albuminuria, low-density 
      lipoprotein-cholesterol, and triglycerides, and lower estimated glomerular 
      filtration rate and high-density lipoprotein-cholesterol. Mortality was higher in 
      those who developed CHD compared with those who did not, with all-cause death in 
      30.2% and 7.8% of patients, respectively. Over 21,641 and 22 049 person-years 
      follow up, 4.4% of patients (n = 169) developed CHD and 8.8% (n = 340) died, 
      respectively. The relative risk of SBP for CHD was constant up to 120 mmHg, after 
      which it started to rise: from 130 mmHg, each 10-mmHg increase in SBP was 
      associated with a 1.13-fold increased risk of CHD. CONCLUSIONS: We identified 130 
      mmHg as the threshold of SBP for increased risk of CHD in Chinese female patients 
      with T2DM. It appears that 67-77 mmHg is the optimal range for diastolic BP, 
      within which the risk of CHD is lowest.
FAU - Ma, Ronald Ching Wan
AU  - Ma RC
AD  - Department of Medicine and Therapeutics, The Chinese University of Hong Kong, 
      Hong Kong, SAR, China.
FAU - Yang, Xilin
AU  - Yang X
FAU - Ko, Gary Tin Choi
AU  - Ko GT
FAU - So, Wing Yee
AU  - So WY
FAU - Kong, Alice Pik Shan
AU  - Kong AP
FAU - Ho, Chung Shun
AU  - Ho CS
FAU - Lam, Christopher Wai Kei
AU  - Lam CW
FAU - Chow, Chun Chung
AU  - Chow CC
FAU - Tong, Peter Chun Yip
AU  - Tong PC
FAU - Chan, Juliana Chung Ngor
AU  - Chan JC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Australia
TA  - J Diabetes
JT  - Journal of diabetes
JID - 101504326
SB  - IM
MH  - Aged
MH  - Albuminuria/metabolism
MH  - Asian People
MH  - Blood Pressure/*physiology
MH  - Cohort Studies
MH  - Coronary Disease/*epidemiology/etiology/*mortality
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Female
MH  - Hong Kong
MH  - Humans
MH  - Incidence
MH  - Middle Aged
MH  - Prospective Studies
MH  - Registries
MH  - Risk Factors
MH  - Smoking
EDAT- 2009/06/01 00:00
MHDA- 2011/02/04 06:00
CRDT- 2010/10/09 06:00
PHST- 2010/10/09 06:00 [entrez]
PHST- 2009/06/01 00:00 [pubmed]
PHST- 2011/02/04 06:00 [medline]
AID - JDB023 [pii]
AID - 10.1111/j.1753-0407.2009.00023.x [doi]
PST - ppublish
SO  - J Diabetes. 2009 Jun;1(2):90-8. doi: 10.1111/j.1753-0407.2009.00023.x.