PMID- 20929509
OWN - NLM
STAT- MEDLINE
DCOM- 20110203
LR  - 20221207
IS  - 1753-0407 (Electronic)
IS  - 1753-0407 (Linking)
VI  - 1
IP  - 2
DP  - 2009 Jun
TI  - Serum retinol-binding protein 4 is associated with insulin secretion in Chinese 
      people with normal glucose tolerance.
PG  - 125-30
LID - 10.1111/j.1753-0407.2009.00024.x [doi]
AB  - BACKGROUND: Serum levels of retinol-binding protein 4 (RBP4) are associated with 
      insulin resistance and type 2 diabetes mellitus (T2DM) and may impact on beta-cell 
      function. Thus, the present study investigated the relationship between serum 
      RBP4 and insulin secretion in Chinese people with and without T2DM. METHODS: A 75 
      g oral glucose tolerance test was administered to all 867 subjects and serum RBP4 
      concentrations were determined. Insulin secretion was assessed by DeltaI/DeltaG 
      (increment in plasma insulin concentration/plasma glucose concentration 30 min 
      after the oral administration of 75 g glucose) and the total area under the curve 
      for insulin over 180 min (AUC-I). Magnetic resonance imaging was used to measure 
      visceral fat area (VFA) at L4-L5; subjects with VFA >/=80 cm(2) were considered to 
      have visceral obesity (VO). RESULTS: Serum RBP4 concentrations were significantly 
      higher in subjects with VO than without, regardless of the presence of T2DM. In 
      addition, in the entire group with normal glucose tolerance (NGT), serum RBP4 was 
      positively correlated with DeltaI/DeltaG (r = 0.152; P < 0.01) and AUC-I (r = 0.218; P < 
      0.01) after adjustment for gender. The correlation between RBP4 and DeltaI/DeltaG (r =  
      0.162; P < 0.05) and AUC-I (r = 0.195; P < 0.01) remained in NGT non-VO subjects. 
      No correlation was found between serum RBP4 and DeltaI/DeltaG or AUC-I in T2DM patients. 
      Stepwise multiple regression analysis showed that serum RBP4 is an independent 
      factor that contributes to DeltaI/DeltaG (beta = 0.176) and AUC-I (beta = 0.204) in NGT non-VO 
      subjects. CONCLUSIONS: Serum RBP4 is correlated with glucose-stimulated insulin 
      secretion in NGT non-VO subjects, but not in NGT VO subjects and T2DM patients.
FAU - Li, Ling
AU  - Li L
AD  - Department of Endocrinology and Metabolism, Shanghai Jiaotong University 
      Affiliated Sixth People's Hospital.
FAU - Wang, Chen
AU  - Wang C
FAU - Bao, Yuqian
AU  - Bao Y
FAU - Wu, Haiya
AU  - Wu H
FAU - Lu, Junxi
AU  - Lu J
FAU - Xiang, Kunsan
AU  - Xiang K
FAU - Jia, Weiping
AU  - Jia W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Australia
TA  - J Diabetes
JT  - Journal of diabetes
JID - 101504326
RN  - 0 (Insulin)
RN  - 0 (RBP4 protein, human)
RN  - 0 (Retinol-Binding Proteins, Plasma)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Asian People
MH  - Diabetes Mellitus, Type 2/metabolism
MH  - Female
MH  - Glucose Intolerance
MH  - Glucose Tolerance Test
MH  - Humans
MH  - Insulin/*blood
MH  - Insulin Resistance/physiology
MH  - Intra-Abdominal Fat
MH  - Male
MH  - Middle Aged
MH  - Retinol-Binding Proteins, Plasma/*metabolism
EDAT- 2009/06/01 00:00
MHDA- 2011/02/04 06:00
CRDT- 2010/10/09 06:00
PHST- 2010/10/09 06:00 [entrez]
PHST- 2009/06/01 00:00 [pubmed]
PHST- 2011/02/04 06:00 [medline]
AID - JDB024 [pii]
AID - 10.1111/j.1753-0407.2009.00024.x [doi]
PST - ppublish
SO  - J Diabetes. 2009 Jun;1(2):125-30. doi: 10.1111/j.1753-0407.2009.00024.x.