PMID- 20929543
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1742-6405 (Electronic)
IS  - 1742-6405 (Linking)
VI  - 7
DP  - 2010 Oct 7
TI  - Multi-analyte profiling of ten cytokines in South African HIV-infected patients 
      with Immune Reconstitution Inflammatory Syndrome (IRIS).
PG  - 36
LID - 10.1186/1742-6405-7-36 [doi]
AB  - BACKGROUND: Immune reconstitution inflammatory syndrome (IRIS) is an important 
      complication of HAART in sub-Saharan Africa, where opportunistic infections (OIs) 
      including mycobacteria and cryptococcus are common. The immune system's role in 
      HIV infected patients is complex with cytokine expression strongly influencing 
      HIV infection and replication. METHODS: We determined the expression patterns of 
      10 cytokines by Luminex multi-analyte profiling in 17 IRIS nested case-control 
      pairs participating in a prospective South African cohort initiating 
      anti-retroviral therapy. RESULTS: Interferon-gamma (IFN-gamma) expression was 
      significantly elevated in IRIS cases compared to controls (median 9.88 pg/ml 
      versus 2.68 pg/ml, respectively, P = 0.0057), while other cytokines displayed 
      non-significant differences in expression. Significant correlation was observed 
      between IL-6, IL-10, and IFN-gamma expression in the IRIS patients. CONCLUSIONS: 
      Significantly increased expression levels of IFN-gamma suggest that this cytokine 
      possibly plays a role in IRIS pathology and is a potential diagnostic marker.
FAU - Worsley, Catherine M
AU  - Worsley CM
AD  - Department of Molecular Medicine and Haematology, Faculty of Health Sciences, 
      University of the Witwatersrand and National Health Laboratory Services, 
      Johannesburg, South Africa. catherine.worsley@nhls.ac.za.
FAU - Suchard, Melinda S
AU  - Suchard MS
FAU - Stevens, Wendy S
AU  - Stevens WS
FAU - Van Rie, Annelies
AU  - Van Rie A
FAU - Murdoch, David M
AU  - Murdoch DM
LA  - eng
GR  - K01 TW008005/TW/FIC NIH HHS/United States
GR  - P30 AI050410/AI/NIAID NIH HHS/United States
GR  - P30 AI064518/AI/NIAID NIH HHS/United States
PT  - Journal Article
DEP - 20101007
PL  - England
TA  - AIDS Res Ther
JT  - AIDS research and therapy
JID - 101237921
PMC - PMC2992027
EDAT- 2010/10/12 06:00
MHDA- 2010/10/12 06:01
PMCR- 2010/10/07
CRDT- 2010/10/09 06:00
PHST- 2010/07/13 00:00 [received]
PHST- 2010/10/07 00:00 [accepted]
PHST- 2010/10/09 06:00 [entrez]
PHST- 2010/10/12 06:00 [pubmed]
PHST- 2010/10/12 06:01 [medline]
PHST- 2010/10/07 00:00 [pmc-release]
AID - 1742-6405-7-36 [pii]
AID - 10.1186/1742-6405-7-36 [doi]
PST - epublish
SO  - AIDS Res Ther. 2010 Oct 7;7:36. doi: 10.1186/1742-6405-7-36.