PMID- 20929697
OWN - NLM
STAT- MEDLINE
DCOM- 20110225
LR  - 20181023
IS  - 1308-0032 (Electronic)
IS  - 1302-8723 (Linking)
VI  - 10
IP  - 5
DP  - 2010 Oct
TI  - Relation of homocysteine levels with patency and flow rate of infarct-related 
      artery in patients receiving fibrinolytic therapy.
PG  - 410-5
LID - 10.5152/akd.2010.138 [doi]
AB  - OBJECTIVE: Elevated homocysteine levels induce a hypercoagulable state and make 
      the clot more resistant to fibrinolysis. In this prospective observational study, 
      we investigated the influence of homocysteine levels on infarct-related artery 
      (IRA) patency and flow as determined with regard to thrombolysis in myocardial 
      infraction (TIMI) flow grade and corrected TIMI frame count (CTFC). METHODS: 
      Sixty-one patients who received fibrinolytic therapy for a first ST elevation 
      myocardial infarction (STEMI) within 12 hours of chest pain were included. 
      Coronary angiography was performed according to the Judkins technique within 72 
      hours after fibrinolytic therapy. Total plasma homocysteine level was determined 
      by the high-performance liquid chromatography method with fluorescence detection. 
      Statistical analysis was performed using Chi-square, Student's t and Pearson 
      correlation tests. Logistic regression analysis was used to determine the 
      predictors of IRA occlusion. RESULTS: Of the 61 patients, 22 (36.1%) had an 
      occluded IRA (group 1), 39 (63.9%) had a patent IRA (group 2). Mean plasma 
      homocysteine levels were found to be significantly higher in the group 1 compared 
      to the group 2 (18.5+/-9.6 micromol/L vs 14.3+/-5 micromol/L, p=0.04). In addition, we found 
      a significant positive correlation between CTFC and plasma homocysteine levels 
      (r=0.415; p=0.01). In multiple logistic regression analysis, high levels of 
      plasma homocysteine (OR=1.2; 95% CI 1.1-1.25; p=0.03) and being a non-smoker 
      (OR=5.9; 95% CI 1.1-31.6; p=0.03) were found to be significant independent 
      predictors of having an occluded IRA. CONCLUSION: There is an inverse relation 
      between plasma homocysteine levels and IRA patency and flow in patients receiving 
      fibrinolytic therapy for STEMI.
FAU - Keles, Telat
AU  - Keles T
AD  - Cardiology Clinic, Ataturk Education and Research Hospital, Ankara, Turkey. 
      drtelatkeles@yahoo.com
FAU - Yeter, Ekrem
AU  - Yeter E
FAU - Durmaz, Tahir
AU  - Durmaz T
FAU - Akar Bayram, Nihal
AU  - Akar Bayram N
FAU - Akcay, Murat
AU  - Akcay M
FAU - Ayhan, Huseyin
AU  - Ayhan H
FAU - Bozkurt, Engin
AU  - Bozkurt E
LA  - eng
PT  - Journal Article
PL  - Turkey
TA  - Anadolu Kardiyol Derg
JT  - Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology
JID - 101095069
RN  - 0 (Biomarkers)
RN  - 0 (Fibrinolytic Agents)
RN  - 0LVT1QZ0BA (Homocysteine)
SB  - IM
MH  - Biomarkers/blood
MH  - Blood Flow Velocity/*physiology
MH  - Chest Pain/etiology
MH  - Chromatography, High Pressure Liquid
MH  - Coronary Angiography
MH  - Fibrinolytic Agents/*therapeutic use
MH  - Homocysteine/*blood
MH  - Humans
MH  - Myocardial Infarction/diagnostic imaging/*drug therapy
MH  - Patient Selection
MH  - Regression Analysis
EDAT- 2010/10/12 06:00
MHDA- 2011/02/26 06:00
CRDT- 2010/10/09 06:00
PHST- 2010/10/09 06:00 [entrez]
PHST- 2010/10/12 06:00 [pubmed]
PHST- 2011/02/26 06:00 [medline]
AID - 10.5152/akd.2010.138 [doi]
PST - ppublish
SO  - Anadolu Kardiyol Derg. 2010 Oct;10(5):410-5. doi: 10.5152/akd.2010.138.