PMID- 20930031
OWN - NLM
STAT- MEDLINE
DCOM- 20110222
LR  - 20101108
IS  - 1758-1001 (Electronic)
IS  - 0004-5632 (Linking)
VI  - 47
IP  - Pt 6
DP  - 2010 Nov
TI  - Monoclonal free light chains can be found in heavy chain diseases.
PG  - 570-2
LID - 10.1258/acb.2010.010146 [doi]
AB  - Heavy chain diseases (HCDs) are rare B-cell lymphoproliferative neoplasias 
      characterized by the production of a monoclonal component consisting of a 
      truncated monoclonal Ig heavy chain without the associated light chain. Among 
      them, patients with gamma-HCD are so rare that no more than 150 cases can be 
      found in the literature. In this paper, we report one additional case: an 
      83-year-old man with a gamma-HCD, in whom a kappa light chain component was 
      detected in the serum by using the serum free light-chain assessment and in 
      addition monoclonal kappa cytoplasmic expression was detected in bone marrow 
      plasma cells by flow cytometric analysis. In the work-up of the patient, the 
      underlying anatomopathological lymphoproliferative disease corresponded to a 
      lymphoplasmacytic lymphoma, as it is stated in the current World Health 
      Organization classification (2008), with both lymphadenopathic and bone marrow 
      infiltration. As in other cases, several autoimmune manifestations 
      (antiphospholipidic syndrome and immune thrombocytopenia) were present during the 
      course of the disease in this patient. This case report illustrates a new case of 
      gamma-HCD, in which serum free light-chain analysis and flow cytometry 
      represented a valuable tool for diagnosis, a finding that could be very important 
      for the future management of these patients.
FAU - Lopez-Anglada, L
AU  - Lopez-Anglada L
AD  - Haematology Department, University Hospital of Salamanca, Paseo San Vicente 
      58-182, Salamanca, Spain.
FAU - Puig, N
AU  - Puig N
FAU - Diez-Campelo, M
AU  - Diez-Campelo M
FAU - Alonso-Ralero, L
AU  - Alonso-Ralero L
FAU - Barrena, S
AU  - Barrena S
FAU - Aparicio, M A
AU  - Aparicio MA
FAU - Gutierrez, N C
AU  - Gutierrez NC
FAU - Garcia-Sanz, R
AU  - Garcia-Sanz R
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101007
PL  - England
TA  - Ann Clin Biochem
JT  - Annals of clinical biochemistry
JID - 0324055
RN  - 0 (Immunoglobulin gamma-Chains)
SB  - IM
MH  - Aged, 80 and over
MH  - Flow Cytometry
MH  - Heavy Chain Disease/*blood/*diagnosis
MH  - Humans
MH  - Immunoglobulin gamma-Chains/*blood
MH  - Male
EDAT- 2010/10/12 06:00
MHDA- 2011/02/23 06:00
CRDT- 2010/10/09 06:00
PHST- 2010/10/09 06:00 [entrez]
PHST- 2010/10/12 06:00 [pubmed]
PHST- 2011/02/23 06:00 [medline]
AID - acb.2010.010146 [pii]
AID - 10.1258/acb.2010.010146 [doi]
PST - ppublish
SO  - Ann Clin Biochem. 2010 Nov;47(Pt 6):570-2. doi: 10.1258/acb.2010.010146. Epub 
      2010 Oct 7.