PMID- 20931529
OWN - NLM
STAT- MEDLINE
DCOM- 20110224
LR  - 20101008
IS  - 1003-9406 (Print)
IS  - 1003-9406 (Linking)
VI  - 27
IP  - 5
DP  - 2010 Oct
TI  - [Molecular genetics of autoimmune diabetes].
PG  - 521-3
LID - 10.3760/cma.j.issn.1003-9406.2010.05.010 [doi]
AB  - Autoimmune diabetes is a T cell-mediated disease characterized by the autoimmune 
      destruction of pancreatic beta-cells and insulin deficiency. It is related to 
      multiple genes. The IDDM1 locus, which lies within the human leukocyte antigen 
      (HLA) and the IDDM2 locus, which is located to the insulin gene region, are two 
      major genetic contributors of susceptibility. Many other loci conferring 
      susceptibility to autoimmune diabetes are being discovered, including PTPN22, 
      CTLA4, IL2RA and IFIH1. In this article, these loci and their possible 
      immunologic mechanisms involved in the pathogenesis of this disease will be 
      reviewed.
FAU - Zha, Min
AU  - Zha M
AD  - Department of Endocrinology, the First Affiliated Hospital, Nanjing Medical 
      University, Nanjing, Jiangsu, P.R. China.
FAU - Yang, Tao
AU  - Yang T
FAU - Chen, Jia-wei
AU  - Chen JW
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - China
TA  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi
JT  - Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese 
      journal of medical genetics
JID - 9425197
SB  - IM
MH  - Animals
MH  - Diabetes Mellitus, Type 1/*genetics/*immunology/pathology
MH  - Genetic Predisposition to Disease
MH  - Humans
EDAT- 2010/10/12 06:00
MHDA- 2011/02/25 06:00
CRDT- 2010/10/09 06:00
PHST- 2010/10/09 06:00 [entrez]
PHST- 2010/10/12 06:00 [pubmed]
PHST- 2011/02/25 06:00 [medline]
AID - 940627104 [pii]
AID - 10.3760/cma.j.issn.1003-9406.2010.05.010 [doi]
PST - ppublish
SO  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2010 Oct;27(5):521-3. doi: 
      10.3760/cma.j.issn.1003-9406.2010.05.010.