PMID- 20931685
OWN - NLM
STAT- MEDLINE
DCOM- 20110204
LR  - 20190723
IS  - 1365-4632 (Electronic)
IS  - 0011-9059 (Linking)
VI  - 49
IP  - 10
DP  - 2010 Oct
TI  - Human leukocyte antigen (HLA) and single nucleotide polymorphisms (SNPs) tumor 
      necrosis factor (TNF)-alpha -238 and -308 as genetic markers of susceptibility to 
      psoriasis and severity of the disease in a long-term follow-up Brazilian study.
PG  - 1133-40
AB  - BACKGROUND: The strongest genetic marker for psoriasis is Cw*06. Polymorphisms in 
      the tumor necrosis factor (TNF)-alpha promoter region, especially replacement of 
      guanine with adenine in positions -238 and -308 are related to higher TNF-alpha 
      production and higher risk for psoriasis in Caucasoid populations, not found in 
      Asians. We performed a case-control study of 69 patients with psoriasis type I 
      and 70 controls, characterized clinical progression along 10-years of follow-up 
      in mild or severe disease and determined HLA class I, II, and TNF single 
      nucleotide polymorphisms (SNPs) -238 and -308 polymorphisms to demonstrate 
      whether these polymorphisms may be genetic risk for susceptibility to psoriasis 
      or severity of the disease in Brazilians. METHODS: Polymorphisms were identified 
      using PCR/SSP. Alleles, genotypes, and haplotypes frequencies were compared using 
      Fisher's test. RESULTS: More severe disease was found in male patients. It may be 
      suggested that alleles B*37, Cw*06, Cw*12, and DRB1*07 were associated with 
      severe disease course, while B*57 with mild disease. No statistical difference 
      was found between the patients and controls regarding polymorphisms frequencies 
      in TNF SNPs. This study pointed to a higher TNF-238 G/G genotype frequency (OR: 
      3.21; CI: 1.06-9.71; P = 0.04) in the group with severe disease. CONCLUSIONS: 
      Polymorphisms in the TNF-alpha SNPs do not seem to be a more important genetic 
      risk factor for psoriasis than the already known Cw*06 in Brazilian patients, but 
      these markers may be related to clinical manifestations.
CI  - (c) 2010 The International Society of Dermatology.
FAU - Magalhaes, Renata Ferreira
AU  - Magalhaes RF
AD  - Immunogenetic Transplant Laboratory, Department of Clinical Pathology, Faculty of 
      Medical Sciences, University of Campinas, Campinas, Brazil.
FAU - Biral, Ana Cristina
AU  - Biral AC
FAU - Pancoto, Joao Alexandre Tres
AU  - Pancoto JA
FAU - Donadi, Eduardo Antonio
AU  - Donadi EA
FAU - Mendes, Celso Texeira Jr
AU  - Mendes CT Jr
FAU - Magna, Luis Antonio
AU  - Magna LA
FAU - Kraemer, Maria Helena
AU  - Kraemer MH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Int J Dermatol
JT  - International journal of dermatology
JID - 0243704
RN  - 0 (Genetic Markers)
RN  - 0 (HLA Antigens)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Brazil
MH  - Case-Control Studies
MH  - Female
MH  - Follow-Up Studies
MH  - Gene Frequency
MH  - Genetic Markers
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA Antigens/*genetics
MH  - Haplotypes
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymerase Chain Reaction
MH  - *Polymorphism, Single Nucleotide
MH  - Promoter Regions, Genetic
MH  - Psoriasis/*genetics
MH  - *Severity of Illness Index
MH  - Tumor Necrosis Factor-alpha/*genetics
MH  - Young Adult
EDAT- 2010/10/12 06:00
MHDA- 2011/02/05 06:00
CRDT- 2010/10/09 06:00
PHST- 2010/10/09 06:00 [entrez]
PHST- 2010/10/12 06:00 [pubmed]
PHST- 2011/02/05 06:00 [medline]
AID - 10.1111/j.1365-4632.2010.04465.x [doi]
PST - ppublish
SO  - Int J Dermatol. 2010 Oct;49(10):1133-40. doi: 10.1111/j.1365-4632.2010.04465.x.