PMID- 20931787
OWN - NLM
STAT- MEDLINE
DCOM- 20120813
LR  - 20221207
IS  - 0513-4870 (Print)
IS  - 0513-4870 (Linking)
VI  - 45
IP  - 7
DP  - 2010 Jul
TI  - [Application of Fourier amplitude sensitivity test in Chinese healthy volunteer 
      population pharmacokinetic model of tacrolimus].
PG  - 883-90
AB  - In this study, we evaluated the influence of different variance from each of the 
      parameters on the output of tacrolimus population pharmacokinetic (PopPK) model 
      in Chinese healthy volunteers, using Fourier amplitude sensitivity test (FAST). 
      Besides, we estimated the index of sensitivity within whole course of blood 
      sampling, designed different sampling times, and evaluated the quality of 
      parameters' and the efficiency of prediction. It was observed that besides CL1/F, 
      the index of sensitivity for all of the other four parameters (V1/F, V2/F, CL2/F 
      and k(a)) in tacrolimus PopPK model showed relatively high level and changed fast 
      with the time passing. With the increase of the variance of k(a), its indices of 
      sensitivity increased obviously, associated with significant decrease in 
      sensitivity index for the other parameters, and obvious change in peak time as 
      well. According to the simulation of NONMEM and the comparison among different 
      fitting results, we found that the sampling time points designed according to 
      FAST surpassed the other time points. It suggests that FAST can access the 
      sensitivities of model parameters effectively, and assist the design of clinical 
      sampling times and the construction of PopPK model.
FAU - Guan, Zheng
AU  - Guan Z
AD  - The State Key Laboratory of Natural and Biomimetic Drugs, Peking University, 
      Beijing 100191, China.
FAU - Zhang, Guan-min
AU  - Zhang GM
FAU - Ma, Ping
AU  - Ma P
FAU - Liu, Li-hong
AU  - Liu LH
FAU - Zhou, Tian-yan
AU  - Zhou TY
FAU - Lu, Wei
AU  - Lu W
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Yao Xue Xue Bao
JT  - Yao xue xue bao = Acta pharmaceutica Sinica
JID - 21710340R
RN  - 0 (Immunosuppressive Agents)
RN  - WM0HAQ4WNM (Tacrolimus)
SB  - IM
MH  - Administration, Oral
MH  - Adult
MH  - Asian People
MH  - Fourier Analysis
MH  - Humans
MH  - Immunosuppressive Agents/administration & dosage/blood/*pharmacokinetics
MH  - *Models, Biological
MH  - Nonlinear Dynamics
MH  - Sensitivity and Specificity
MH  - Tacrolimus/administration & dosage/blood/*pharmacokinetics
MH  - Young Adult
EDAT- 2010/10/12 06:00
MHDA- 2012/08/14 06:00
CRDT- 2010/10/12 06:00
PHST- 2010/10/12 06:00 [entrez]
PHST- 2010/10/12 06:00 [pubmed]
PHST- 2012/08/14 06:00 [medline]
PST - ppublish
SO  - Yao Xue Xue Bao. 2010 Jul;45(7):883-90.