PMID- 20933343
OWN - NLM
STAT- MEDLINE
DCOM- 20111207
LR  - 20161125
IS  - 1879-355X (Electronic)
IS  - 0360-3016 (Linking)
VI  - 81
IP  - 3
DP  - 2011 Nov 1
TI  - [(1)(8)F]FDG-positron emission tomography coregistration with computed tomography 
      scans for radiation treatment planning of lymphoma and hematologic malignancies.
PG  - 615-22
LID - 10.1016/j.ijrobp.2010.06.044 [doi]
AB  - PURPOSE: Positron emission-tomography (PET) using 2-[(18)F]fluoro-2-deoxyglucose 
      (FDG-PET) increases sensitivity and specificity of disease detection in lymphoma 
      and thus is standard in lymphoma management. This study examines the effects of 
      coregistering FDG-PET and computed tomography (CT) (PET/CT) scans on treatment 
      planning for lymphoma patients. METHODS AND MATERIALS: Twenty-nine patients (30 
      positive PET scans) underwent PET/CT treatment planning from July 2004 to 
      February 2007 and were retrospectively studied. For each patient, gross tumor 
      volume was blindly contoured on the CT-only and PET/CT studies by a radiation 
      oncologist. Treatment plans were generated for both the CT-only and PET/CT 
      planning target volumes (PTVs) for all patients. Normal tissue doses and PTV 
      coverage were evaluated using dose--volume histograms for all sites. RESULTS: 
      Thirty-two treatment sites were evaluated. Twenty-one patients had non-Hodgkin 
      lymphoma, 5 patients had Hodgkin lymphoma, and 3 patients had plasma cell 
      neoplasms. Previously undetected FDG-avid sites were identified in 3 patients 
      during PET/CT simulation, resulting in one additional treatment field. Due to 
      unexpected PET/CT simulation findings, 2 patients did not proceed with radiation 
      treatment. The addition of PET changed the volume of 23 sites (72%). The PTV was 
      increased in 15 sites (47%) by a median of 11% (range, 6-40%) and reduced in 8 
      sites (25%) by a median of 20% (range, 6%-75%). In six (19%) replanned sites, the 
      CT-based treatment plan would not have adequately covered the PTV defined by 
      PET/CT. CONCLUSIONS: Incorporation of FDG-PET into CT-based treatment planning 
      for lymphoma patients resulted in considerable changes in management, volume 
      definition, and normal tissue dosimetry for a significant number of patients.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Terezakis, Stephanie A
AU  - Terezakis SA
AD  - Department of Radiation Oncology Medical Physics, Memorial Sloan-Kettering Cancer 
      Center, New York, New York 10021, USA.
FAU - Hunt, Margie A
AU  - Hunt MA
FAU - Kowalski, Alexander
AU  - Kowalski A
FAU - McCann, Patrick
AU  - McCann P
FAU - Schmidtlein, C Ross
AU  - Schmidtlein CR
FAU - Reiner, Anne
AU  - Reiner A
FAU - Gonen, Mithat
AU  - Gonen M
FAU - Kirov, Assen S
AU  - Kirov AS
FAU - Gonzales, Anne Marie
AU  - Gonzales AM
FAU - Schoder, Heiko
AU  - Schoder H
FAU - Yahalom, Joachim
AU  - Yahalom J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101008
PL  - United States
TA  - Int J Radiat Oncol Biol Phys
JT  - International journal of radiation oncology, biology, physics
JID - 7603616
RN  - 0 (Radiopharmaceuticals)
RN  - 0Z5B2CJX4D (Fluorodeoxyglucose F18)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Cancer Care Facilities
MH  - Female
MH  - *Fluorodeoxyglucose F18
MH  - Hodgkin Disease/*diagnostic imaging/radiotherapy
MH  - Humans
MH  - Lymphoma, Non-Hodgkin/*diagnostic imaging/radiotherapy
MH  - Male
MH  - Middle Aged
MH  - Multimodal Imaging/*methods
MH  - Neoplasms, Plasma Cell/*diagnostic imaging/radiotherapy
MH  - New York City
MH  - *Positron-Emission Tomography
MH  - *Radiopharmaceuticals
MH  - Radiotherapy Planning, Computer-Assisted/*methods
MH  - Retrospective Studies
MH  - *Tomography, X-Ray Computed
MH  - Tumor Burden
MH  - Young Adult
EDAT- 2010/10/12 06:00
MHDA- 2011/12/13 00:00
CRDT- 2010/10/12 06:00
PHST- 2009/11/20 00:00 [received]
PHST- 2010/06/18 00:00 [revised]
PHST- 2010/06/25 00:00 [accepted]
PHST- 2010/10/12 06:00 [entrez]
PHST- 2010/10/12 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - S0360-3016(10)00895-3 [pii]
AID - 10.1016/j.ijrobp.2010.06.044 [doi]
PST - ppublish
SO  - Int J Radiat Oncol Biol Phys. 2011 Nov 1;81(3):615-22. doi: 
      10.1016/j.ijrobp.2010.06.044. Epub 2010 Oct 8.