PMID- 20934257
OWN - NLM
STAT- MEDLINE
DCOM- 20110927
LR  - 20191210
IS  - 1873-3360 (Electronic)
IS  - 0306-4530 (Linking)
VI  - 36
IP  - 5
DP  - 2011 Jun
TI  - Alterations in cognitive function and behavioral response to amphetamine induced 
      by prenatal inflammation are dependent on the stage of pregnancy.
PG  - 634-48
LID - 10.1016/j.psyneuen.2010.09.006 [doi]
AB  - Maternal infection during human pregnancy has been associated with the 
      development of schizophrenia in the adult offspring. The stage of development and 
      the maternal inflammatory response to infection, which undergoes quantitative and 
      qualitative changes throughout gestation, are thought to determine critical 
      windows of vulnerability for the developing brain. In order to investigate how 
      these two factors may contribute to the outcome in the offspring, we studied the 
      inflammatory response to turpentine (TURP) injection (100 mul/dam) and its 
      consequences in the adult offspring, in pregnant rats at gestational day (GD) 15 
      or 18, which correspond to late first and early second trimester of human 
      pregnancy, respectively. Maternal inflammatory response to TURP was different 
      between the two GDs, with fever and circulating levels of the pro-inflammatory 
      interleukin (IL)-6 significantly attenuated at GD 18, compared to GD 15. In the 
      adult offspring, TURP challenge at GD 15 induced a significant decrease in 
      pre-pulse inhibition (PPI) of acoustic startle, increased latency in the cued 
      task of the Morris-water maze, prolonged conditioned fear response and enhanced 
      locomotor effect of amphetamine. In contrast, the same immune challenge at GD 18 
      induced only a prolonged conditioned fear response. These results suggest a 
      window of vulnerability at GD 15, at which TURP seems to affect several behaviors 
      that are strongly modulated by dopamine. This was supported by increased tyrosine 
      hydroxylase expression in the nucleus accumbens of the adult offspring of mothers 
      treated at GD 15.
CI  - Copyright (c) 2010 Elsevier Ltd. All rights reserved.
FAU - Aguilar-Valles, Argel
AU  - Aguilar-Valles A
AD  - Douglas Mental Health University Institute, Department of Psychiatry, McGill 
      University, Montreal, Quebec, Canada.
FAU - Luheshi, Giamal N
AU  - Luheshi GN
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101012
PL  - England
TA  - Psychoneuroendocrinology
JT  - Psychoneuroendocrinology
JID - 7612148
RN  - 0 (Amphetamines)
RN  - 0 (Irritants)
RN  - XJ6RUH0O4G (Turpentine)
SB  - IM
MH  - Amphetamines/*metabolism/*pharmacology
MH  - Animals
MH  - Behavior, Animal/*drug effects
MH  - Cognition/*drug effects/physiology
MH  - Female
MH  - Gestational Age
MH  - Inflammation/complications/*metabolism
MH  - Irritants/adverse effects
MH  - Pregnancy
MH  - Pregnancy Complications/metabolism/pathology
MH  - Prenatal Exposure Delayed Effects/*physiopathology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reflex, Startle/drug effects/physiology
MH  - Turpentine/adverse effects
EDAT- 2010/10/12 06:00
MHDA- 2011/09/29 06:00
CRDT- 2010/10/12 06:00
PHST- 2010/07/13 00:00 [received]
PHST- 2010/09/07 00:00 [revised]
PHST- 2010/09/09 00:00 [accepted]
PHST- 2010/10/12 06:00 [entrez]
PHST- 2010/10/12 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - S0306-4530(10)00239-8 [pii]
AID - 10.1016/j.psyneuen.2010.09.006 [doi]
PST - ppublish
SO  - Psychoneuroendocrinology. 2011 Jun;36(5):634-48. doi: 
      10.1016/j.psyneuen.2010.09.006. Epub 2010 Oct 12.