PMID- 20934770 OWN - NLM STAT- MEDLINE DCOM- 20110321 LR - 20220410 IS - 1872-8227 (Electronic) IS - 0168-8227 (Linking) VI - 90 IP - 3 DP - 2010 Dec TI - Evidence on the applicability of the ATPIII, IDF and CDS metabolic syndrome diagnostic criteria to identify CVD and T2DM in the Chinese population from a 6.3-year cohort study in mid-eastern China. PG - 319-25 LID - 10.1016/j.diabres.2010.09.001 [doi] AB - AIMS: This study evaluates the effectiveness of three metabolic syndrome (MS) criteria in identifying cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM) in the Chinese population. METHODS: 3598 subjects were recruited from a cohort study on Prevention of Multiple Metabolic disorders and MS in Jiangsu of China (PMMJS), followed at 6.3 years. MS was diagnosed using criteria of the National Cholesterol Education Program's Adult Treatment Panel III (ATPIII), the International Diabetes Federation (IDF) and Chinese Diabetes Society (CDS). Cox regression model was used to analysis the association between MS and onset of CVD and T2DM. Receiver operating characteristic (ROC) curve, sensitivity and specificity were also used to test the ability of three MS criteria to identify CVD or T2DM. RESULTS: Among three criteria, CDS has the highest specificity but lowest sensitivity. Using the CDS criterion, over 50 percent of patients would be misdiagnosed. ATPIII criterion has the shortest distance in ROC curve, lowest false positive rate and false negative rate for identifying CVD and T2DM. ATPIII+/IDF+ has lower ability to predict CVD than ATPIII+/IDF-. ATPIII+/IDF+ and ATPIII+/IDF- has similar ability to predict T2DM. CONCLUSIONS: The ATPIII-MS criterion has the highest ability to predict CVD and T2DM. ATPIII is the best MS criterion for the Chinese population. CI - Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved. FAU - Zhou, Hui AU - Zhou H AD - Center for Disease Control and Prevention of Suzhou Industry Park, SuZhou, JiangSu, China. FAU - Guo, Zhi-rong AU - Guo ZR FAU - Yu, Lu-gang AU - Yu LG FAU - Hu, Xiao-shu AU - Hu XS FAU - Xu, Bao-hui AU - Xu BH FAU - Liu, Hai-bo AU - Liu HB FAU - Wu, Ming AU - Wu M FAU - Zhou, Zheng-yuan AU - Zhou ZY LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20101008 PL - Ireland TA - Diabetes Res Clin Pract JT - Diabetes research and clinical practice JID - 8508335 SB - IM MH - Adult MH - Aged MH - Cardiovascular Diseases/*diagnosis MH - China/epidemiology MH - Cohort Studies MH - Diabetes Mellitus, Type 2/*diagnosis/epidemiology MH - False Negative Reactions MH - False Positive Reactions MH - Female MH - Humans MH - Male MH - Metabolic Syndrome/*diagnosis/epidemiology MH - Middle Aged MH - Prevalence MH - ROC Curve MH - Risk Factors MH - Sensitivity and Specificity EDAT- 2010/10/12 06:00 MHDA- 2011/03/22 06:00 CRDT- 2010/10/12 06:00 PHST- 2009/10/21 00:00 [received] PHST- 2010/08/22 00:00 [revised] PHST- 2010/09/02 00:00 [accepted] PHST- 2010/10/12 06:00 [entrez] PHST- 2010/10/12 06:00 [pubmed] PHST- 2011/03/22 06:00 [medline] AID - S0168-8227(10)00446-8 [pii] AID - 10.1016/j.diabres.2010.09.001 [doi] PST - ppublish SO - Diabetes Res Clin Pract. 2010 Dec;90(3):319-25. doi: 10.1016/j.diabres.2010.09.001. Epub 2010 Oct 8.