PMID- 20936992
OWN - NLM
STAT- MEDLINE
DCOM- 20101207
LR  - 20211020
IS  - 1532-4303 (Electronic)
IS  - 0277-0903 (Print)
IS  - 0277-0903 (Linking)
VI  - 47
IP  - 9
DP  - 2010 Nov
TI  - Exhaled NO among inner-city children in New York City.
PG  - 1015-21
LID - 10.3109/02770903.2010.513075 [doi]
AB  - BACKGROUND: Fractional exhaled nitric oxide (FeNO) has been proposed as a 
      biomarker of airway inflammation for cohort studies of asthma. OBJECTIVES: To 
      assess the association between FeNO and asthma symptoms among 7-year-old children 
      living in an inner-city community. To test the association between environmental 
      tobacco smoke (ETS) exposure (previous and current) and FeNO among these 
      children. METHODS: As part of a longitudinal study of asthma, children recruited 
      in Head Start centers at age 4 had offline FeNO and lung function testing at age 
      7. Children with allergen-specific immunoglobulin E (IgE) (>/=0.35 IU/mL) at age 7 
      were considered seroatopic. ETS exposure at ages 4 and 7 was assessed by 
      questionnaire. RESULTS: Of 144 participating children, 89 had complete 
      questionnaire data and achieved valid FeNO and lung function tests. Children with 
      reported wheeze in the previous 12 months (n = 19) had higher FeNO than those 
      without wheeze (n = 70) (geometric means 17.0 vs. 11.0 ppb, p = .005). FeNO 
      remained significantly associated with wheeze (p = .031), after adjusting for 
      seroatopy and forced expiratory volume in 1 second (FEV(1)) in multivariable 
      regression. FeNO at age 7 was positively associated with domestic ETS exposure at 
      age 4 (29%) (beta = 0.36, p = .015) but inversely associated with ETS exposure at 
      age 7 (16%) (beta = -0.74, p < .001). CONCLUSIONS: Given its association with 
      current wheeze, independent of seroatopy and lung function, FeNO provides a 
      relevant outcome measure for studies in inner-city communities. While compelling, 
      the positive association between ETS exposure at age 4 and a marker of airway 
      inflammation at age 7 should be confirmed in a larger study.
FAU - Perzanowski, Matthew S
AU  - Perzanowski MS
AD  - Department of Environmental Health Sciences, Mailman School of Public Health, 
      Columbia University, New York, NY 10032, USA. mp2217@columbia.edu
FAU - Divjan, Adnan
AU  - Divjan A
FAU - Mellins, Robert B
AU  - Mellins RB
FAU - Canfield, Stephen M
AU  - Canfield SM
FAU - Rosa, Maria Jose
AU  - Rosa MJ
FAU - Chew, Ginger L
AU  - Chew GL
FAU - Rundle, Andrew
AU  - Rundle A
FAU - Goldstein, Inge F
AU  - Goldstein IF
FAU - Jacobson, Judith S
AU  - Jacobson JS
LA  - eng
GR  - P30 ES009089/ES/NIEHS NIH HHS/United States
GR  - R01 HL068236/HL/NHLBI NIH HHS/United States
GR  - HL068236/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - England
TA  - J Asthma
JT  - The Journal of asthma : official journal of the Association for the Care of 
      Asthma
JID - 8106454
RN  - 0 (Biomarkers)
RN  - 0 (Tobacco Smoke Pollution)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Asthma/*diagnosis/physiopathology
MH  - Biomarkers/analysis
MH  - Body Mass Index
MH  - Breath Tests
MH  - Child
MH  - Child, Preschool
MH  - Cohort Studies
MH  - *Exhalation
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Inhalation Exposure/*adverse effects
MH  - Longitudinal Studies
MH  - Male
MH  - New York City
MH  - Nitric Oxide/*analysis
MH  - Poverty
MH  - Tobacco Smoke Pollution/*analysis
MH  - Urban Population
PMC - PMC3056403
MID - NIHMS268126
COIS- Declaration of Interest: The authors report no conflicts of interest. The authors 
      alone are responsible for the content and writing of the paper.
EDAT- 2010/10/13 06:00
MHDA- 2010/12/14 06:00
PMCR- 2011/11/01
CRDT- 2010/10/13 06:00
PHST- 2010/10/13 06:00 [entrez]
PHST- 2010/10/13 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
PHST- 2011/11/01 00:00 [pmc-release]
AID - 10.3109/02770903.2010.513075 [doi]
PST - ppublish
SO  - J Asthma. 2010 Nov;47(9):1015-21. doi: 10.3109/02770903.2010.513075.