PMID- 20937324 OWN - NLM STAT- MEDLINE DCOM- 20110310 LR - 20181201 IS - 1873-2518 (Electronic) IS - 0264-410X (Linking) VI - 28 IP - 51 DP - 2010 Nov 29 TI - Endemic diphtheria in Ho Chi Minh City; Viet Nam: a matched case-control study to identify risk factors of incidence. PG - 8141-6 LID - 10.1016/j.vaccine.2010.09.088 [doi] AB - From 1999 to 2004, Ho Chi Minh City (HCMC), Vie Nam reported 401 clinically suspected and 90 laboratory-confirmed diphtheria. To identify risk factors, a matched case-control study was conducted during 2005 and 2006. In total, 88 cases that occurred in 2003 and 2004 and 352 age- and sex-matched controls were studied. No DPT/DT immunisation (odds ratio, 9.9 [95% CI, 1.9-52.3]) and bathing only once a day or less (OR 1.7 [95% CI, 1.0-2.9]) were associated with diphtheria incidence. Estimated vaccine efficacy of three or more DPT/DT doses was 88%. Immunising children with zero-dose status of diphtheria toxoid inoculation, rather than the introduction of booster doses, and the promotion of skin hygiene were considered to be the priority interventions in controlling the endemic diphtheria in HCMC. CI - Copyright (c) 2010 Elsevier Ltd. All rights reserved. FAU - Murakami, Hitoshi AU - Murakami H AD - Department of International Medical Cooperation, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku, Tokyo 162-8655, Japan. murakami@it.ncgm.go.jp FAU - Phuong, Nguyen M AU - Phuong NM FAU - Thang, Ho V AU - Thang HV FAU - Chau, Nguyen V AU - Chau NV FAU - Giao, Pham N AU - Giao PN FAU - Tho, Nguyen D AU - Tho ND LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - Netherlands TA - Vaccine JT - Vaccine JID - 8406899 RN - 0 (Diphtheria Toxoid) SB - IM MH - Adolescent MH - Case-Control Studies MH - Child MH - Child, Preschool MH - Cities MH - Diphtheria/*epidemiology MH - Diphtheria Toxoid/administration & dosage MH - Female MH - Humans MH - Incidence MH - Infant MH - Male MH - Risk Factors MH - Urban Population MH - Vaccination/statistics & numerical data MH - Vietnam/epidemiology EDAT- 2010/10/13 06:00 MHDA- 2011/03/11 06:00 CRDT- 2010/10/13 06:00 PHST- 2010/06/01 00:00 [received] PHST- 2010/09/18 00:00 [revised] PHST- 2010/09/26 00:00 [accepted] PHST- 2010/10/13 06:00 [entrez] PHST- 2010/10/13 06:00 [pubmed] PHST- 2011/03/11 06:00 [medline] AID - S0264-410X(10)01430-1 [pii] AID - 10.1016/j.vaccine.2010.09.088 [doi] PST - ppublish SO - Vaccine. 2010 Nov 29;28(51):8141-6. doi: 10.1016/j.vaccine.2010.09.088.