PMID- 20937338
OWN - NLM
STAT- MEDLINE
DCOM- 20111202
LR  - 20101220
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 72
IP  - 1
DP  - 2011 Jan
TI  - HLA-A, -B, -C, -DQB1, and -DRB1,3,4,5 allele and haplotype frequencies in the 
      Costa Rica Central Valley Population and its relationship to worldwide 
      populations.
PG  - 80-6
LID - 10.1016/j.humimm.2010.10.005 [doi]
AB  - The human leukocyte antigen (HLA) system is the most polymorphic in humans. Its 
      allele, genotype, and haplotype frequencies vary significantly among different 
      populations. Molecular typing data on HLA are necessary for the development of 
      stem cell donor registries, cord blood banks, HLA-disease association studies, 
      and anthropology studies. The Costa Rica Central Valley Population (CCVP) is the 
      major population in this country. No previous study has characterized HLA 
      frequencies in this population. Allele group and haplotype frequencies of HLA 
      genes in the CCVP were determined by means of molecular typing in a sample of 130 
      unrelated blood donors from one of the country's major hospitals. A comparison 
      between these frequencies and those of 126 populations worldwide was also carried 
      out. A minimum variance dendrogram based on squared Euclidean distances was 
      constructed to assess the relationship between the CCVP sample and populations 
      from all over the world. Allele group and haplotype frequencies observed in this 
      study are consistent with a profile of a dynamic and diverse population, with a 
      hybrid ethnic origin, predominantly Caucasian-Amerindian. Results showed that 
      populations genetically closest to the CCVP are a Mestizo urban population from 
      Venezuela, and another one from Guadalajara, Mexico.
CI  - Copyright (c) 2011 American Society for Histocompatibility and Immunogenetics. All 
      rights reserved.
FAU - Arrieta-Bolanos, Esteban
AU  - Arrieta-Bolanos E
AD  - Centro de Investigaciones en Hematologia y Trastornos Afines (CIHATA), Hospital 
      San Juan de Dios, San Jose, Costa Rica. esteban.arrietabolanos@ucr.ac.cr
FAU - Maldonado-Torres, Hazael
AU  - Maldonado-Torres H
FAU - Dimitriu, Oana
AU  - Dimitriu O
FAU - Hoddinott, Michael A
AU  - Hoddinott MA
FAU - Fowles, Finnuala
AU  - Fowles F
FAU - Shah, Anila
AU  - Shah A
FAU - Orlich-Perez, Priscilla
AU  - Orlich-Perez P
FAU - McWhinnie, Alasdair J
AU  - McWhinnie AJ
FAU - Alfaro-Bourrouet, Wilbert
AU  - Alfaro-Bourrouet W
FAU - Bujan-Boza, Willem
AU  - Bujan-Boza W
FAU - Little, Ann-Margaret
AU  - Little AM
FAU - Salazar-Sanchez, Lizbeth
AU  - Salazar-Sanchez L
FAU - Madrigal, J Alejandro
AU  - Madrigal JA
LA  - eng
PT  - Journal Article
DEP - 20101028
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Analysis of Variance
MH  - Cluster Analysis
MH  - Costa Rica
MH  - *Gene Frequency
MH  - Haplotypes
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Histocompatibility Antigens Class II/*genetics
MH  - Histocompatibility Testing
MH  - Humans
MH  - Linkage Disequilibrium/genetics
MH  - Population Groups/genetics
EDAT- 2010/10/13 06:00
MHDA- 2011/12/13 00:00
CRDT- 2010/10/13 06:00
PHST- 2010/02/22 00:00 [received]
PHST- 2010/09/27 00:00 [revised]
PHST- 2010/10/04 00:00 [accepted]
PHST- 2010/10/13 06:00 [entrez]
PHST- 2010/10/13 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - S0198-8859(10)00519-7 [pii]
AID - 10.1016/j.humimm.2010.10.005 [doi]
PST - ppublish
SO  - Hum Immunol. 2011 Jan;72(1):80-6. doi: 10.1016/j.humimm.2010.10.005. Epub 2010 
      Oct 28.