PMID- 20938461
OWN - NLM
STAT- MEDLINE
DCOM- 20110217
LR  - 20211020
IS  - 1759-5053 (Electronic)
IS  - 1759-5045 (Linking)
VI  - 7
IP  - 11
DP  - 2010 Nov
TI  - Esomeprazole-induced hyperchromograninemia in the absence of concomitant 
      hypergastrinemia.
PG  - 642-6
LID - 10.1038/nrgastro.2010.152 [doi]
AB  - BACKGROUND: A 37-year-old female, who had a neuroendocrine pancreatic neoplasm, 
      underwent duodeno-cephalo-pancreatectomy. In the 2 years following surgery, she 
      had normal levels of serum chromogranin A (CgA), gastrin and other tumor markers. 
      About 3 years after surgery, owing to the onset of reflux-like dyspeptic 
      symptoms, the patient started treatment with the PPI esomeprazole. During PPI 
      treatment, the patient's serum CgA level rose to more than three times the upper 
      limit of normal, although her gastrin levels remained in the normal range. These 
      findings were interpreted as being suggestive of neuroendocrine tumor relapse. 
      INVESTIGATIONS: Thoraco-abdominal CT, In(1)(1)(1)-octreotide total body scan, CT of 
      sella turcica, Tc(99m)-sestamibi neck scan, mutational analysis of chromosome 
      11q13 (site of multiple endocrine neoplasia type 1 [MEN1] gene). Discontinuation 
      of, and rechallenge with, esomeprazole. DIAGNOSIS: Esomeprazole-induced 
      hyperchromograninemia in the absence of elevated levels of fasting serum gastrin. 
      MANAGEMENT: Discontinuation of acid-suppressive treatment and continuation of 
      oncologic follow-up.
FAU - Gori, Giovanni
AU  - Gori G
AD  - Division of Pharmacology and Chemotherapy, Department of Internal Medicine, 
      University of Pisa, via Roma, 55-56126 Pisa, Italy.
FAU - Spinelli, Giacomo
AU  - Spinelli G
FAU - Spinelli, Claudio
AU  - Spinelli C
FAU - Tuccori, Marco
AU  - Tuccori M
FAU - Blandizzi, Corrado
AU  - Blandizzi C
FAU - Del Tacca, Mario
AU  - Del Tacca M
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20101012
PL  - England
TA  - Nat Rev Gastroenterol Hepatol
JT  - Nature reviews. Gastroenterology & hepatology
JID - 101500079
RN  - 0 (Anti-Ulcer Agents)
RN  - 0 (Chromogranin A)
RN  - 0 (Gastrins)
RN  - N3PA6559FT (Esomeprazole)
SB  - IM
MH  - Adult
MH  - Anti-Ulcer Agents/*adverse effects
MH  - Chromogranin A/*blood
MH  - Education, Medical, Continuing
MH  - Esomeprazole/*adverse effects
MH  - Female
MH  - Gastrins/*blood
MH  - Gastroesophageal Reflux/blood/complications/*drug therapy
MH  - Humans
MH  - Neuroendocrine Tumors/complications
EDAT- 2010/10/13 06:00
MHDA- 2011/02/18 06:00
CRDT- 2010/10/13 06:00
PHST- 2010/10/13 06:00 [entrez]
PHST- 2010/10/13 06:00 [pubmed]
PHST- 2011/02/18 06:00 [medline]
AID - nrgastro.2010.152 [pii]
AID - 10.1038/nrgastro.2010.152 [doi]
PST - ppublish
SO  - Nat Rev Gastroenterol Hepatol. 2010 Nov;7(11):642-6. doi: 
      10.1038/nrgastro.2010.152. Epub 2010 Oct 12.