PMID- 20938749
OWN - NLM
STAT- MEDLINE
DCOM- 20110613
LR  - 20211020
IS  - 1614-7499 (Electronic)
IS  - 0944-1344 (Linking)
VI  - 18
IP  - 4
DP  - 2011 May
TI  - Geospatial patterns of hospitalization rates for stroke with comorbid 
      hypertension in relation to environmental sources of persistent organic 
      pollutants: results from a 12-year population-based study.
PG  - 576-85
LID - 10.1007/s11356-010-0399-7 [doi]
AB  - PURPOSE: Recent evidence indicates that exposure to persistent organic pollutants 
      (POPs) is emerging as an important risk factor for atherosclerosis-related 
      diseases, including stroke. Hypertension (HTN) is a major risk factor for stroke, 
      and some studies suggest that exposure to POPs is also a risk factor for HTN. We 
      hypothesized that POPs increase the environmental burden of stroke with comorbid 
      HTN. METHODS: A population-based study of hospitalization rates for stroke with 
      comorbid HTN in populations presumably exposed to POPs, based on the zip code of 
      residence, was conducted. Data on hospitalizations for stroke with comorbid HTN 
      were obtained from the New York Statewide Planning and Research Cooperative 
      System for 1993-2004. Relative risks, with 95% confidence intervals (RR, 95% CI), 
      of hospitalization were estimated by multiple Poisson regression analysis. 
      RESULTS: RR of hospitalization for stroke with comorbid HTN was 13.4% higher in 
      populations residing in zip codes containing or abutting environmental sources of 
      POPs (RR = 1.134; 95% CI, 1.036-1.241; p = 0.006). Also, hospitalization rates 
      were significantly higher in males than in females (RR = 1.397; 95% CI, 
      1.357-1.437; p < 0.001), in African Americans than in Caucasians (RR = 3.902; 95% 
      CI, 3.617-4.208; p < 0.001), and in older age groups (p for trend < 0.001). These 
      statistically significant findings of the effect of demographic factors are 
      highly consistent with the current knowledge of stroke and serve as indirect 
      quality indicators for our model. CONCLUSIONS: Results of our study support the 
      hypothesis that exposure to POPs increases the environmental burden of both 
      stroke and HTN.
FAU - Sergeev, Alexander V
AU  - Sergeev AV
AD  - Department of Social and Public Health, Ohio University, Grover Center W343, 
      Athens, OH 45701, USA. sergeev@ohio.edu
FAU - Carpenter, David O
AU  - Carpenter DO
LA  - eng
GR  - TW000636/TW/FIC NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20101012
PL  - Germany
TA  - Environ Sci Pollut Res Int
JT  - Environmental science and pollution research international
JID - 9441769
RN  - 0 (Environmental Pollutants)
RN  - 0 (Organic Chemicals)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Comorbidity
MH  - Cross-Sectional Studies
MH  - Environmental Exposure/statistics & numerical data
MH  - Environmental Pollutants/*analysis
MH  - Environmental Pollution/*statistics & numerical data
MH  - Female
MH  - Hospitalization/*statistics & numerical data
MH  - Humans
MH  - Hypertension/*epidemiology
MH  - Male
MH  - Middle Aged
MH  - New York/epidemiology
MH  - Organic Chemicals/*analysis
MH  - Stroke/*epidemiology
EDAT- 2010/10/13 06:00
MHDA- 2011/06/15 06:00
CRDT- 2010/10/13 06:00
PHST- 2009/12/31 00:00 [received]
PHST- 2010/09/27 00:00 [accepted]
PHST- 2010/10/13 06:00 [entrez]
PHST- 2010/10/13 06:00 [pubmed]
PHST- 2011/06/15 06:00 [medline]
AID - 10.1007/s11356-010-0399-7 [doi]
PST - ppublish
SO  - Environ Sci Pollut Res Int. 2011 May;18(4):576-85. doi: 
      10.1007/s11356-010-0399-7. Epub 2010 Oct 12.