PMID- 20939666
OWN - NLM
STAT- MEDLINE
DCOM- 20110209
LR  - 20161125
IS  - 1939-0084 (Electronic)
IS  - 0735-7044 (Linking)
VI  - 124
IP  - 5
DP  - 2010 Oct
TI  - Behavioral profiles in rats distinguish among "ecstasy," methamphetamine and 
      2,5-dimethoxy-4-iodoamphetamine: Mixed effects for "ecstasy" analogues.
PG  - 662-76
LID - 10.1037/a0020827 [doi]
AB  - 3,4-methylenedioxymethamphetamine (MDMA; "ecstasy") is a psychoactive drug 
      structurally related to other phenylisopropylamines acting as stimulants or 
      hallucinogens in humans. Although MDMA has a pharmacological identity of its own, 
      the distinction of its acute effects from those of stimulants or even 
      hallucinogens is controversial. In this work, dose-response curves (0.25, 0.5, 1, 
      3, 5, and 10 mg/kg) representing the acute in vivo effects of MDMA were compared 
      with those of a structurally related stimulant (methamphetamine, MA) and a 
      hallucinogenic analogue (2,5-dimethoxy-4-iodoamphetamine, DOI) in a set of 
      behavioral protocols in rats, including spontaneous psychomotor activity, 
      anxiolytic/anxiogenic-like effects and active avoidance conditioning responses. 
      The behavioral profiles obtained allowed us to differentiate among racemic MDMA, 
      MA, and DOI at different dose ranges. In addition, the evaluation of four MDMA 
      analogues (1, 5, and 10 mg/kg) comprising two well-known MDMA analogues (MDA 
      [3,4-methylenedioxyamphetamine] and MDE (N-ethyl-MDA, believed to substitute for 
      MDMA) and two other structural analogues (MDOH [N-hydroxy-MDA] and MMDA-2 
      [2-methoxy-4,5-methylenedioxyamphetamine]) showed that none of these exactly 
      resembles MDMA in their pharmacological profiles, highlighting the unique 
      character of this prototypical entactogen. In fact, their effects exhibited 
      similarities with the behavioral profiles of either MA or DOI, as well as novel 
      profiles in specific behavioral paradigms.
CI  - (PsycINFO Database Record (c) 2010 APA, all rights reserved).
FAU - Quinteros-Munoz, David
AU  - Quinteros-Munoz D
AD  - School of Medicine, Faculty of Medical Sciences, University of Santiago de Chile, 
      Avda. Bdo. O'Higgins 3363, Estacion Central, Santiago, Chile.
FAU - Saez-Briones, Patricio
AU  - Saez-Briones P
FAU - Diaz-Veliz, Gabriela
AU  - Diaz-Veliz G
FAU - Mora-Gutierrez, Sergio
AU  - Mora-Gutierrez S
FAU - Rebolledo-Fuentes, Marco
AU  - Rebolledo-Fuentes M
FAU - Cassels, Bruce K
AU  - Cassels BK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Behav Neurosci
JT  - Behavioral neuroscience
JID - 8302411
RN  - 0 (Amphetamines)
RN  - 0 (Central Nervous System Stimulants)
RN  - 0 (Hallucinogens)
RN  - 44RAL3456C (Methamphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - OOM10GW9UE (4-iodo-2,5-dimethoxyphenylisopropylamine)
SB  - IM
MH  - Amphetamines/*pharmacology
MH  - Animals
MH  - Avoidance Learning/drug effects
MH  - Behavior, Animal/*drug effects
MH  - Central Nervous System Stimulants/pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Hallucinogens/pharmacology
MH  - Male
MH  - Maze Learning/drug effects
MH  - Methamphetamine/*pharmacology
MH  - Motor Activity/drug effects
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*analogs & derivatives/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2010/10/14 06:00
MHDA- 2011/02/10 06:00
CRDT- 2010/10/14 06:00
PHST- 2010/10/14 06:00 [entrez]
PHST- 2010/10/14 06:00 [pubmed]
PHST- 2011/02/10 06:00 [medline]
AID - 2010-20760-010 [pii]
AID - 10.1037/a0020827 [doi]
PST - ppublish
SO  - Behav Neurosci. 2010 Oct;124(5):662-76. doi: 10.1037/a0020827.