PMID- 20941371
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1662-5129 (Electronic)
IS  - 1662-5129 (Linking)
VI  - 4
DP  - 2010
TI  - Lungfishes, like tetrapods, possess a vomeronasal system.
LID - 130 [pii]
LID - 10.3389/fnana.2010.00130 [doi]
AB  - The vomeronasal system (VNS) is an accessory olfactory system that in tetrapod 
      vertebrates is composed of specific receptor neurons in the nasal organ and a set 
      of centers in the forebrain that receive and relay the information consecutively 
      towards the hypothalamus. Thus, only in tetrapods the VNS comprises a discrete 
      vomeronasal (Jacobson's) organ, which contains receptor cells that are 
      morphologically distinct from those of the olfactory epithelium and use different 
      transduction mechanisms. The axons of the vomeronasal receptors in tetrapods 
      project to the accessory olfactory bulb (AOB) in the rostral telencephalon. 
      Secondary vomeronasal connections exist through the medial amygdala to the 
      hypothalamus. Currently, the lungfishes are considered the closest living 
      relatives of tetrapods. Here we show that the African lungfish, Protopterus 
      dolloi, has epithelial crypts at the base of the lamellae of the olfactory 
      epithelium that express markers of the vomeronasal receptors in tetrapods. The 
      projections of these crypts allow us to identify an AOB on the lateral margin of 
      the main olfactory bulb. The projections of this AOB reach a region that is 
      topologically, hodologically, and immunohistochemically identical to the medial 
      amygdala and could represent its homolog. Neurons of this putative medial 
      amygdala were demonstrated to project to the lateral hypothalamus, as they do in 
      tetrapods. All these features that lungfishes share with tetrapods indicate that 
      lungfishes have the complete set of brain centers and connections involved in 
      processing vomeronasal information and that these features were already present 
      in the last common ancestor of lungfishes and tetrapods.
FAU - Gonzalez, Agustin
AU  - Gonzalez A
AD  - Department of Cell Biology, Faculty of Biology, University Complutense of Madrid 
      Madrid, Spain.
FAU - Morona, Ruth
AU  - Morona R
FAU - Lopez, Jesus M
AU  - Lopez JM
FAU - Moreno, Nerea
AU  - Moreno N
FAU - Northcutt, R Glenn
AU  - Northcutt RG
LA  - eng
PT  - Journal Article
DEP - 20100901
PL  - Switzerland
TA  - Front Neuroanat
JT  - Frontiers in neuroanatomy
JID - 101477943
PMC - PMC2951178
OTO - NOTNLM
OT  - accessory olfactory bulb
OT  - evolution
OT  - homology
OT  - lobe-finned fish
OT  - medial amygdala
EDAT- 2010/10/14 06:00
MHDA- 2010/10/14 06:01
PMCR- 2010/01/01
CRDT- 2010/10/14 06:00
PHST- 2010/01/19 00:00 [received]
PHST- 2010/07/31 00:00 [accepted]
PHST- 2010/10/14 06:00 [entrez]
PHST- 2010/10/14 06:00 [pubmed]
PHST- 2010/10/14 06:01 [medline]
PHST- 2010/01/01 00:00 [pmc-release]
AID - 130 [pii]
AID - 10.3389/fnana.2010.00130 [doi]
PST - epublish
SO  - Front Neuroanat. 2010 Sep 1;4:130. doi: 10.3389/fnana.2010.00130. eCollection 
      2010.