PMID- 20942236
OWN - NLM
STAT- MEDLINE
DCOM- 20110825
LR  - 20101014
IS  - 2096-7993 (Print)
IS  - 2096-7993 (Linking)
VI  - 24
IP  - 15
DP  - 2010 Aug
TI  - [Expression and significance of integrins subunits in laryngeal squamous cell 
      carcinoma].
PG  - 686-9
AB  - OBJECTIVE: This study was to investigate the expression and significance of 
      Integrins subunits in laryngeal squamous cell carcinoma (LSCC). METHOD: The 
      expression of Integrins subunits was detected by cDNA microarray in 4 cases of 
      primary LSCC tissues and corresponding adjacent normal tissues. Semi-quantitative 
      reverse transcription polymerase chain reaction (RT-PCR) were used to identify 
      the different expression of Integrins subunits in 24 cases of primary LSCC 
      tissues and corresponding adjacent normal tissues. RESULT: A cDNA microarray 
      analysis revealed significant changes in the expression of Integrins subunits, 
      with IntegrinalphaV, Integrinbeta8 being up-regulated and Integrinalpha8 being 
      down-regulated. The result of RT-PCR was consistent with that of cDNA microarray. 
      The mRNA levels of IntegrinalphaV and Integrinbeta8 were significantly higher in 
      LSCC tissues than that in corresponding adjacent normal tissues (1.0131 +/- 
      0.4780 vs 0.7591 +/- 0.4678 for IntegrinalphaV, P<0.05, 1.7362 +/- 1.3849 vs 
      1.2267 +/- 0.9363 for Integrinbeta8, P<0.05). The mRNA levels of Integrinalpha8 
      were significantly lower in LSCC tissues than that in corresponding adjacent 
      normal tissues (0.2646 +/- 0.2622 vs 0.5457 +/- 0.3827, P<0.05). CONCLUSION: The 
      expression of IntegrinalphaV, Integrinbeta8, Integrinalpha8 were significantly 
      up-regulated or down-regulated in laryngeal squamous cell carcinoma, which may 
      relate to tumorigenesis and development of laryngeal squamous cell carcinoma.
FAU - Ni, Rongsheng
AU  - Ni R
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Nanjing BenQ Hospital 
      (the Affiliated Hospital of Nanjing Medical University), Nanjing, 210008, China.
FAU - Shen, Xiaohui
AU  - Shen X
FAU - Wu, Haiyan
AU  - Wu H
FAU - Zhu, Wenyan
AU  - Zhu W
FAU - Ni, Jie
AU  - Ni J
FAU - Huang, Zhenghua
AU  - Huang Z
FAU - Song, Yongling
AU  - Song Y
FAU - Gao, Xia
AU  - Gao X
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
JT  - Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical 
      otorhinolaryngology, head, and neck surgery
JID - 101303164
RN  - 0 (Integrin alpha Chains)
RN  - 0 (Integrin alphaV)
RN  - 0 (Integrin beta Chains)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (integrin alpha8)
RN  - 0 (integrin beta8)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Squamous Cell/*metabolism/pathology
MH  - Humans
MH  - Integrin alpha Chains/genetics/*metabolism
MH  - Integrin alphaV/genetics/*metabolism
MH  - Integrin beta Chains/genetics/*metabolism
MH  - Laryngeal Neoplasms/*metabolism/pathology
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Proteins/metabolism
MH  - Neoplasm Staging
EDAT- 2010/10/15 06:00
MHDA- 2011/08/27 06:00
CRDT- 2010/10/15 06:00
PHST- 2010/10/15 06:00 [entrez]
PHST- 2010/10/15 06:00 [pubmed]
PHST- 2011/08/27 06:00 [medline]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2010 Aug;24(15):686-9.