PMID- 20943718
OWN - NLM
STAT- MEDLINE
DCOM- 20110419
LR  - 20151119
IS  - 1477-0962 (Electronic)
IS  - 0961-2033 (Linking)
VI  - 20
IP  - 1
DP  - 2011 Jan
TI  - Simultaneous detection of anti-C1q and anti-double stranded DNA autoantibodies in 
      lupus nephritis: predictive value for renal flares.
PG  - 28-34
LID - 10.1177/0961203310379871 [doi]
AB  - Clinical difficulties in predicting systemic lupus erythematosus (SLE) renal 
      flares are still encountered. Biological markers such as autoantibodies (aAbs) 
      may be of major interest for clinicians in the follow-up of SLE patients. The aim 
      of our study was to investigate the clinical utility of one of these biological 
      markers, anti-C1q aAbs, in predicting renal flares of SLE nephritis in comparison 
      with the 'gold standard' anti-double stranded DNA (anti-dsDNA) aAbs. Anti-C1q 
      aAbs and anti-dsDNA aAbs were analysed through a longitudinal retrospective study 
      of 23 SLE patients presenting with one or more renal flares. Anti-C1q and/or 
      anti-dsDNA aAbs were found in 20 (87%) of 23 patients, of whom 16 (69%) displayed 
      both. Thirty-three renal flares occurred during the course of the study, and 
      anti-C1q aAbs and anti-dsDNA aAbs were positive in 25 (76%) and 24 (73%) of these 
      flares respectively. The sensitivity of anti-C1q and/or anti-dsDNA aAbs in 
      predicting renal flares reached 85%. The specificity of anti-C1q aAbs was 84%, of 
      anti-dsDNA aAbs 77% and of both aAbs 97%. Positive and negative predictive values 
      were as follows: 56% and 70% for anti-C1q aAbs, 53% and 72% for anti-dsDNA aAbs. 
      The combination of both aAbs had the highest positive predictive value (69%), 
      whereas absence of both aAbs was associated with the highest negative predictive 
      value (74%). In conclusion, our results confirm that anti-C1q aAbs are present in 
      a significant percentage of SLE patients with active renal involvement, 
      suggesting that these aAbs could be a useful additional marker. The presence of 
      anti-C1q and anti-dsDNA aAbs was associated with a high risk of renal flare, 
      whereas the absence of both aAbs excluded such an event. These data confirm that 
      systematic detection of anti-C1q and anti-dsDNA aAbs is of interest for the 
      follow-up in SLE patients with renal involvement.
FAU - Matrat, A
AU  - Matrat A
AD  - Department of Immunology, Hospices Civils de Lyon, Centre Hospitalier Lyon-Sud, 
      Pierre-Benite, France.
FAU - Veysseyre-Balter, C
AU  - Veysseyre-Balter C
FAU - Trolliet, P
AU  - Trolliet P
FAU - Villar, E
AU  - Villar E
FAU - Dijoud, F
AU  - Dijoud F
FAU - Bienvenu, J
AU  - Bienvenu J
FAU - Fabien, N
AU  - Fabien N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101013
PL  - England
TA  - Lupus
JT  - Lupus
JID - 9204265
RN  - 0 (Antibodies, Antinuclear)
RN  - 0 (Autoantibodies)
RN  - 0 (Biomarkers)
RN  - 80295-33-6 (Complement C1q)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Antibodies, Antinuclear/*analysis/immunology
MH  - Autoantibodies/*analysis/immunology
MH  - Biomarkers
MH  - Complement C1q/*immunology
MH  - DNA/*immunology
MH  - Female
MH  - Humans
MH  - *Kidney/immunology/pathology
MH  - Lupus Nephritis/*immunology/pathology/*physiopathology
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Retrospective Studies
MH  - Sensitivity and Specificity
MH  - Severity of Illness Index
MH  - Young Adult
EDAT- 2010/10/15 06:00
MHDA- 2011/04/20 06:00
CRDT- 2010/10/15 06:00
PHST- 2010/10/15 06:00 [entrez]
PHST- 2010/10/15 06:00 [pubmed]
PHST- 2011/04/20 06:00 [medline]
AID - 0961203310379871 [pii]
AID - 10.1177/0961203310379871 [doi]
PST - ppublish
SO  - Lupus. 2011 Jan;20(1):28-34. doi: 10.1177/0961203310379871. Epub 2010 Oct 13.