PMID- 20945041
OWN - NLM
STAT- MEDLINE
DCOM- 20130131
LR  - 20151119
IS  - 0371-0874 (Print)
IS  - 0371-0874 (Linking)
VI  - 62
IP  - 5
DP  - 2010 Oct 25
TI  - [Glucagon-like peptide 1: a novel therapeutic strategy for Alzheimer's disease].
PG  - 398-406
AB  - There is a close correlation between type 2 diabetes mellitus (T2DM) and 
      Alzheimer's disease (AD) in the course of pathophysiological processes. The 
      neuroprotective action of glucagon-like peptide 1 (GLP-1), a latest drug for 
      clinical treatment of T2DM, is being more deeply investigated at present, and a 
      novel therapeutic strategy for AD with GLP-1 has been proposed boldly. This 
      review mainly discussed the correlation of pathogenesis between T2DM and AD, the 
      synthesis and secretion of GLP-1, the distribution and physiological effects of 
      GLP-1 receptor in the brain, and the progresses on the study of GLP-1 in the 
      treatment of AD.
FAU - Wang, Xiao-Hui
AU  - Wang XH
AD  - Department of Physiology, Key Laboratory for Cellular Physiology of Ministry of 
      Education, Shanxi Medical University, Taiyuan 030001, China.
FAU - Yang, Wei
AU  - Yang W
FAU - Qi, Jin-Shun
AU  - Qi JS
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - China
TA  - Sheng Li Xue Bao
JT  - Sheng li xue bao : [Acta physiologica Sinica]
JID - 20730130R
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (GLP1R protein, human)
RN  - 0 (Glucagon-Like Peptide-1 Receptor)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Receptors, Glucagon)
RN  - 89750-14-1 (Glucagon-Like Peptide 1)
SB  - IM
MH  - Alzheimer Disease/*drug therapy/*physiopathology
MH  - Amyloid beta-Peptides/*drug effects/metabolism
MH  - Animals
MH  - Brain/metabolism
MH  - Diabetes Mellitus, Type 2/physiopathology
MH  - Glucagon-Like Peptide 1/pharmacology/*therapeutic use
MH  - Glucagon-Like Peptide-1 Receptor
MH  - Humans
MH  - Neuroprotective Agents/pharmacology/*therapeutic use
MH  - Receptors, Glucagon/metabolism
EDAT- 2010/10/15 06:00
MHDA- 2013/02/01 06:00
CRDT- 2010/10/15 06:00
PHST- 2010/10/15 06:00 [entrez]
PHST- 2010/10/15 06:00 [pubmed]
PHST- 2013/02/01 06:00 [medline]
PST - ppublish
SO  - Sheng Li Xue Bao. 2010 Oct 25;62(5):398-406.