PMID- 20946527
OWN - NLM
STAT- MEDLINE
DCOM- 20110128
LR  - 20101015
IS  - 1440-1827 (Electronic)
IS  - 1320-5463 (Linking)
VI  - 60
IP  - 11
DP  - 2010 Nov
TI  - Odontogenic myxofibroma with HMGA2 overexpression and HMGA2 rearrangement.
PG  - 760-4
LID - 10.1111/j.1440-1827.2010.02589.x [doi]
AB  - Odontogenic myxofibromas are variants of odontogenic myxomas that contain 
      considerable amounts of collagen fibers in the myxoid stroma. Cytogenetic studies 
      of odontogenic myxomas/myxofibromas have rarely been reported. This report 
      describes the first case of an odontogenic myxofibroma presenting with HMGA2 
      protein overexpression and HMGA2 rearrangement in a 40-year-old woman. A 2.7-cm 
      tumor in the premolar region of the right mandible was curettaged. There was no 
      evidence of recurrence or metastasis at 12 months after the surgery. Histological 
      examination revealed that the tumor comprised spindle or stellate cells with mild 
      nuclear pleomorphism, abundant myxoid matrix and partly dense collagen fibers. 
      Mitotic figures were rarely observed. Immunohistochemically, the tumor cells were 
      diffusely positive for vimentin and HMGA2. Less than 1% of the tumor cells were 
      positive for Ki-67. We detected split signals by interphase fluorescence in situ 
      hybridization (FISH) in paraffin sections using HMGA2 break-apart probes. The 
      breaks were certainly located within or near the HMGA2 gene. No rearrangement of 
      the FUS gene was detected by FISH, implying discrimination from low-grade 
      fibromyxoid sarcoma. It is suggested that HMGA2 rearrangement and HMGA2 protein 
      overexpression may be associated with the tumorigenesis of odontogenic 
      myxomas/myxofibromas, similar to the case for many other benign mesenchymal 
      tumors.
CI  - (c) 2010 The Authors. Pathology International (c) 2010 Japanese Society of Pathology 
      and Blackwell Publishing Asia Pty Ltd.
FAU - Sato, Katsuaki
AU  - Sato K
AD  - Department of Pathology II, Kanazawa Medical University, Ishikawa, Japan. 
      sato-k@kanazawa-med.ac.jp
FAU - Terai, Koichi
AU  - Terai K
FAU - Ozaki, Mamoru
AU  - Ozaki M
FAU - Ueda, Yoshimichi
AU  - Ueda Y
FAU - Katsuda, Shogo
AU  - Katsuda S
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20100813
PL  - Australia
TA  - Pathol Int
JT  - Pathology international
JID - 9431380
RN  - 0 (HMGA2 Protein)
SB  - IM
MH  - Adult
MH  - Female
MH  - Fibroma/genetics/*metabolism/pathology
MH  - HMGA2 Protein/genetics/*metabolism
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization
MH  - Mandibular Neoplasms/genetics/*metabolism/pathology
MH  - Odontogenic Tumors/genetics/*metabolism/pathology
EDAT- 2010/10/16 06:00
MHDA- 2011/02/01 06:00
CRDT- 2010/10/16 06:00
PHST- 2010/10/16 06:00 [entrez]
PHST- 2010/10/16 06:00 [pubmed]
PHST- 2011/02/01 06:00 [medline]
AID - 10.1111/j.1440-1827.2010.02589.x [doi]
PST - ppublish
SO  - Pathol Int. 2010 Nov;60(11):760-4. doi: 10.1111/j.1440-1827.2010.02589.x. Epub 
      2010 Aug 13.