PMID- 20946554
OWN - NLM
STAT- MEDLINE
DCOM- 20110211
LR  - 20220408
IS  - 1542-474X (Electronic)
IS  - 1082-720X (Print)
IS  - 1082-720X (Linking)
VI  - 15
IP  - 4
DP  - 2010 Oct
TI  - Is "hyper response" to cardiac resynchronization therapy in patients with 
      nonischemic cardiomyopathy a recovery, a remission, or a control?
PG  - 321-7
LID - 10.1111/j.1542-474X.2010.00387.x [doi]
AB  - BACKGROUND AND OBJECTIVES: Some patients treated by cardiac resynchronization 
      therapy (CRT) recover "normal" left ventricular (LV) function and functional 
      status. However, whether this "normalization" persists or reverts over time 
      remains unknown. The aim of the present study was to evaluate the long-term 
      outcomes of LV function in patients hyper responder to CRT. METHODS: Eleven 
      consecutive patients with nonischemic dilated cardiomyopathy, sinus rhythm, left 
      bundle branch block (LBBB), New York Heart Association (NYHA) class III or IV, 
      and optimal pharmacological treatment were hyper responder as they fulfilled 
      concurrently the two following criteria: functional recovery (NYHA class I or II) 
      and normalization of LV ejection fraction (LVEF). RESULTS: After a mean follow-up 
      of 65 +/- 30 months between CRT implantation and last evaluation LVEF improved from 
      26 +/- 9 to 59 +/- 6% (P < 0.0001). One patient died from pulmonary embolism 31 
      months after implantation. Three patients exhibited LVEF </= 50% at their last 
      follow-up visit (two at 40% and one at 45%). In eight patients, brief cessation 
      of pacing was feasible (three were pacemaker-dependent). Mean QRS duration 
      decreased from 181 +/- 23 ms to 143 +/- 22 ms (P = 0.006). In one patient, pacing was 
      interrupted for 2 years and LVEF decreased markedly (from 65% to 31%) but 
      returned to normal after a few months when pacing was resumed. CONCLUSION: In 
      hyper responder patients, "normalization" of LV function after CRT persists as 
      long as pacing is maintained with an excellent survival.
CI  - (c)2010, Wiley Periodicals, Inc.
FAU - Castellant, Philippe
AU  - Castellant P
AD  - Department of Cardiology, Hopital de la Cavale Blanche, Brest University 
      Hospital, Boulevard Tanguy Prigent, Brest Cedex, France.
FAU - Orhan, Erwann
AU  - Orhan E
FAU - Bertault-Valls, Valerie
AU  - Bertault-Valls V
FAU - Fatemi, Marjaneh
AU  - Fatemi M
FAU - Etienne, Yves
AU  - Etienne Y
FAU - Blanc, Jean-Jacques
AU  - Blanc JJ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ann Noninvasive Electrocardiol
JT  - Annals of noninvasive electrocardiology : the official journal of the 
      International Society for Holter and Noninvasive Electrocardiology, Inc
JID - 9607443
SB  - IM
MH  - Aged
MH  - Bundle-Branch Block/therapy
MH  - Cardiac Resynchronization Therapy/*methods
MH  - Cardiomyopathy, Dilated/*therapy
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Prospective Studies
MH  - Recovery of Function
MH  - Remission Induction/methods
MH  - Survival Analysis
MH  - Treatment Outcome
MH  - Ventricular Function, Left
PMC - PMC6932168
EDAT- 2010/10/16 06:00
MHDA- 2011/02/12 06:00
PMCR- 2010/10/15
CRDT- 2010/10/16 06:00
PHST- 2010/10/16 06:00 [entrez]
PHST- 2010/10/16 06:00 [pubmed]
PHST- 2011/02/12 06:00 [medline]
PHST- 2010/10/15 00:00 [pmc-release]
AID - ANEC387 [pii]
AID - 10.1111/j.1542-474X.2010.00387.x [doi]
PST - ppublish
SO  - Ann Noninvasive Electrocardiol. 2010 Oct;15(4):321-7. doi: 
      10.1111/j.1542-474X.2010.00387.x.