PMID- 20946939
OWN - NLM
STAT- MEDLINE
DCOM- 20111108
LR  - 20151119
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 487
IP  - 2
DP  - 2011 Jan 7
TI  - Chronic ethanol ingestion, type 2 diabetes mellitus, and brain-derived 
      neurotrophic factor (BDNF) in rats.
PG  - 149-52
LID - 10.1016/j.neulet.2010.10.011 [doi]
AB  - Chronic alcohol consumption contributes to the development of type 2 diabetes 
      mellitus (T2DM) while decreasing the level of brain-derived neurotrophic factor 
      (BDNF). BDNF may be an important regulator of glucose metabolism, so it may be 
      associated with an increased risk for T2DM in alcoholism. We evaluated the 
      association of chronic heavy alcohol exposure, T2DM and BDNF level. Ten week-old 
      type 2 diabetic OLETF rats and non-diabetic LETO rats of similar weight were 
      used. The rats were randomized by weight into four treatment groups: (1) 
      OLETF-Ethanol (O-E, n=13), (2) OLETF-Control (O-C, n=15), (3) LETO-Ethanol (L-E, 
      n=11), and (4) LETO-Control (L-C, n=14). The ethanol groups were fed an 
      isocaloric liquid diet containing ethanol while the control groups were fed with 
      the same diet containing maltose-dextran over a 6-week period using a 
      pair-feeding control model in order to regulate different caloric ingestion. 
      After 6 weeks of feeding, an Intraperitoneal Glucose Tolerance Test (IP-GTT) was 
      performed and BDNF levels were analyzed. Prior to IP-GTT, the mean glucose levels 
      in the O-E, O-C, L-E, and L-C groups were 90.38+/-12.84, 102.13+/-5.04, 95.18+/-6.43, 
      and 102.36+/-4.43mg/dL, respectively. Thirty minutes after intraperitoneal 
      injection, the mean glucose levels were 262.62+/-63.77, 229.07+/-51.30, 163.45+/-26.63, 
      and 156.64+/-34.42mg/dL, respectively; the increased amount of the mean glucose 
      level in the O-E group was significantly higher than that in the O-C group 
      (p<0.05). One hundred twenty minutes after intraperitoneal injection, the mean 
      glucose levels were 167.38+/-45.37, 121.20+/-18.54, 106.73+/-6.94, and 
      104.57+/-9.49mg/dL, respectively; the increased amount of the mean glucose level in 
      the O-E group was significantly higher than that in the O-C group (p<0.01). The 
      difference in mean glucose levels between the O-E group and O-C group was still 
      significant even after adjusting for time (p<0.05). Mean BDNF levels were 
      405.95+/-326.16, 618.23+/-462.15, 749.18+/-599.93, and 1172.00+/-839.17pg/mL, 
      respectively; mean BDNF level in the O-E group was significantly lower than the 
      L-C group (p<0.05). In conclusion, the results of the present study suggest that 
      chronic heavy alcohol ingestion may aggravate T2DM and may possibly lower BDNF 
      level.
CI  - Copyright (c) 2010. Published by Elsevier Ireland Ltd.
FAU - Jung, Kyu-In
AU  - Jung KI
AD  - Department of Psychiatry, St. Paul's Hospital, The Catholic University of Korea 
      College of Medicine, Seoul, South Korea.
FAU - Ju, Anes
AU  - Ju A
FAU - Lee, Hee-Mi
AU  - Lee HM
FAU - Lee, Seong-Su
AU  - Lee SS
FAU - Song, Chan-Hee
AU  - Song CH
FAU - Won, Wang-Youn
AU  - Won WY
FAU - Jeong, Jae-Seung
AU  - Jeong JS
FAU - Hong, Oak-Kee
AU  - Hong OK
FAU - Kim, Jae-Hwa
AU  - Kim JH
FAU - Kim, Dai-Jin
AU  - Kim DJ
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101012
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 3K9958V90M (Ethanol)
SB  - IM
MH  - Alcoholism/*blood/complications
MH  - Animals
MH  - Biomarkers/blood
MH  - Blood Glucose/metabolism
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Chronic Disease
MH  - Diabetes Mellitus, Type 2/*blood/etiology
MH  - Ethanol/*administration & dosage
MH  - Male
MH  - Random Allocation
MH  - Rats
MH  - Rats, Inbred OLETF
MH  - Rats, Long-Evans
EDAT- 2010/10/16 06:00
MHDA- 2011/11/09 06:00
CRDT- 2010/10/16 06:00
PHST- 2010/07/23 00:00 [received]
PHST- 2010/09/09 00:00 [revised]
PHST- 2010/10/05 00:00 [accepted]
PHST- 2010/10/16 06:00 [entrez]
PHST- 2010/10/16 06:00 [pubmed]
PHST- 2011/11/09 06:00 [medline]
AID - S0304-3940(10)01337-6 [pii]
AID - 10.1016/j.neulet.2010.10.011 [doi]
PST - ppublish
SO  - Neurosci Lett. 2011 Jan 7;487(2):149-52. doi: 10.1016/j.neulet.2010.10.011. Epub 
      2010 Oct 12.