PMID- 20949734
OWN - NLM
STAT- MEDLINE
DCOM- 20101102
LR  - 20101018
IS  - 0377-9343 (Print)
IS  - 0377-9343 (Linking)
VI  - 52
IP  - 3
DP  - 2010 Jul-Sep
TI  - Role of corticosteroids in the treatment of tuberculosis: an evidence-based 
      update.
PG  - 153-8
AB  - Corticosteroids are often used as an adjunct in the treatment of various forms of 
      tuberculosis (TB) and for the prevention of complications, such as constrictive 
      pericarditis, hydrocephalus, focal neurological deficits, pleural adhesions, and 
      intestinal strictures. Notwithstanding, they have been proven in clinical trials 
      to improve the following outcomes only--death or disability in human 
      immunodeficiency virus (HIV)-seronegative patients with tubercular meningitis and 
      tubercular pericarditis. Despite a lack of specific evidence for efficacy in HIV 
      co-infected patients with tubercular meningitis or pericarditis, corticosteroids 
      are generally recommended in them as well. Corticosteroids significantly decrease 
      the risk of pleural thickening in patients with tubercular pleural effusion; the 
      clinical significance of this finding, however, is unclear. Recently, it has been 
      demonstrated that use of corticosteroids improve the morbidity in HIV co-infected 
      patients with paradoxical TB immune reconstitution inflammatory syndrome (IRIS). 
      However, evidence favouring the use of corticosteroids in other clinical 
      situations is sparse or lacking. Likewise, the biological mechanisms underlying 
      their beneficial effect in TB meningitis and pericarditis remain poorly 
      understood.
FAU - Kadhiravan, Tamilarasu
AU  - Kadhiravan T
AD  - Department of Medicine, Jawaharlal Institute of Postgraduate Medical Education 
      and Research, Puducherry, India. kadhiravant@yahoo.co.in
FAU - Deepanjali, Surendran
AU  - Deepanjali S
LA  - eng
PT  - Journal Article
PT  - Review
PL  - India
TA  - Indian J Chest Dis Allied Sci
JT  - The Indian journal of chest diseases & allied sciences
JID - 7612044
RN  - 0 (Glucocorticoids)
SB  - IM
MH  - Evidence-Based Medicine
MH  - Glucocorticoids/*therapeutic use
MH  - HIV Infections/complications
MH  - Humans
MH  - Tuberculosis/complications/*drug therapy
EDAT- 2010/10/19 06:00
MHDA- 2010/11/03 06:00
CRDT- 2010/10/19 06:00
PHST- 2010/10/19 06:00 [entrez]
PHST- 2010/10/19 06:00 [pubmed]
PHST- 2010/11/03 06:00 [medline]
PST - ppublish
SO  - Indian J Chest Dis Allied Sci. 2010 Jul-Sep;52(3):153-8.