PMID- 20951386
OWN - NLM
STAT- MEDLINE
DCOM- 20110815
LR  - 20221207
IS  - 1879-1379 (Electronic)
IS  - 0022-3956 (Linking)
VI  - 45
IP  - 5
DP  - 2011 May
TI  - Dysbindin (DTNBP1)--a role in psychotic depression?
PG  - 588-95
LID - 10.1016/j.jpsychires.2010.09.014 [doi]
AB  - Previous studies yielded evidence for dysbindin (DTNBP1) to impact the 
      pathogenesis of schizophrenia on the one hand and affective disorders such as 
      bipolar or major depressive disorder (MDD) on the other. Thus, in the present 
      study we investigated whether DTNBP1 variation was associated with psychotic 
      depression as a severe clinical manifestation of MDD possibly constituting an 
      overlapping phenotype between affective disorders and schizophrenia. A sample of 
      243 Caucasian inpatients with MDD (SCID-I) was genotyped for 12 SNPs spanning 92% 
      of the DTNBP1 gene region. Differences in DTNBP1 genotype distributions across 
      diagnostic subgroups of psychotic (N = 131) vs. non-psychotic depression were 
      estimated by Pearson Chi(2) test and logistic regression analyses adjusted for 
      age, gender, Beck Depression Inventory (BDI) and the Global Assessment of 
      Functioning Scale (GAF). Overall, patients with psychotic depression presented 
      with higher BDI and lower GAF scores expressing a higher severity of the illness 
      as compared to depressed patients without psychotic features. Four DTNBP1 SNPs, 
      particularly rs1997679 and rs9370822, and the corresponding haplotypes, 
      respectively, were found to be significantly associated with the risk of 
      psychotic depression in an allele-dose fashion. In summary, the present results 
      provide preliminary support for dysbindin (DTNBP1) gene variation, particularly 
      SNPs rs1997679 and rs9370822, to be associated with the clinical phenotype of 
      psychotic depression suggesting a possible neurobiological mechanism for an 
      intermediate trait on the continuum between affective disorders and 
      schizophrenia.
CI  - Copyright (c) 2010 Elsevier Ltd. All rights reserved.
FAU - Domschke, Katharina
AU  - Domschke K
AD  - Department of Psychiatry, University of Muenster, Albert-Schweitzer-Strasse 11, 
      D-48143 Muenster, Germany. katharina.domschke@ukmuenster.de
FAU - Lawford, Bruce
AU  - Lawford B
FAU - Young, Ross
AU  - Young R
FAU - Voisey, Joanne
AU  - Voisey J
FAU - Morris, C Phillip
AU  - Morris CP
FAU - Roehrs, Tilmann
AU  - Roehrs T
FAU - Hohoff, Christa
AU  - Hohoff C
FAU - Birosova, Eva
AU  - Birosova E
FAU - Arolt, Volker
AU  - Arolt V
FAU - Baune, Bernhard T
AU  - Baune BT
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101015
PL  - England
TA  - J Psychiatr Res
JT  - Journal of psychiatric research
JID - 0376331
RN  - 0 (Carrier Proteins)
RN  - 0 (DTNBP1 protein, human)
RN  - 0 (Dysbindin)
RN  - 0 (Dystrophin-Associated Proteins)
SB  - IM
MH  - Adult
MH  - Carrier Proteins/*genetics
MH  - Chi-Square Distribution
MH  - Chromosomes, Human, Pair 6/genetics
MH  - Depressive Disorder, Major/complications/*genetics
MH  - Dysbindin
MH  - Dystrophin-Associated Proteins
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Psychiatric Status Rating Scales
MH  - Psychotic Disorders/complications/*genetics
MH  - White People
EDAT- 2010/10/19 06:00
MHDA- 2011/08/16 06:00
CRDT- 2010/10/19 06:00
PHST- 2010/06/08 00:00 [received]
PHST- 2010/08/10 00:00 [revised]
PHST- 2010/09/22 00:00 [accepted]
PHST- 2010/10/19 06:00 [entrez]
PHST- 2010/10/19 06:00 [pubmed]
PHST- 2011/08/16 06:00 [medline]
AID - S0022-3956(10)00281-5 [pii]
AID - 10.1016/j.jpsychires.2010.09.014 [doi]
PST - ppublish
SO  - J Psychiatr Res. 2011 May;45(5):588-95. doi: 10.1016/j.jpsychires.2010.09.014. 
      Epub 2010 Oct 15.