PMID- 20951694
OWN - NLM
STAT- MEDLINE
DCOM- 20110324
LR  - 20181201
IS  - 1879-0712 (Electronic)
IS  - 0014-2999 (Linking)
VI  - 650
IP  - 1
DP  - 2011 Jan 10
TI  - A role for adenosine A(1) receptor blockade in the ability of caffeine to promote 
      MDMA "Ecstasy"-induced striatal dopamine release.
PG  - 220-8
LID - 10.1016/j.ejphar.2010.10.012 [doi]
AB  - Co-administration of caffeine profoundly enhances the acute toxicity of 3,4 
      methylenedioxymethamphetamine (MDMA) in rats. The aim of this study was to 
      determine the ability of caffeine to impact upon MDMA-induced dopamine release in 
      superfused brain tissue slices as a contributing factor to this drug interaction. 
      MDMA (100 and 300muM) induced a dose-dependent increase in dopamine release in 
      striatal and hypothalamic tissue slices preloaded with [(3)H] dopamine (1muM). 
      Caffeine (100muM) also induced dopamine release in the striatum and hypothalamus, 
      albeit to a much lesser extent than MDMA. When striatal tissue slices were 
      superfused with MDMA (30muM) in combination with caffeine (30muM), caffeine 
      enhanced MDMA-induced dopamine release, provoking a greater response than that 
      obtained following either caffeine or MDMA applications alone. The synergistic 
      effects in the striatum were not observed in hypothalamic slices. As adenosine 
      A(1) receptors are, one of the main pharmacological targets of caffeine, which 
      are known to play an important role in the regulation of dopamine release, their 
      role in the modulation of MDMA-induced dopamine release was investigated. 1muM 
      8-cyclopentyl-1,3-dipropylxanthine (DPCPX), a specific A(1) antagonist, like 
      caffeine, enhanced MDMA-induced dopamine release from striatal slices while 1muM 
      2,chloro-N(6)-cyclopentyladenosine (CCPA), a selective adenosine A(1) receptor 
      agonist, attenuated this. Treatment with either SCH 58261, a selective A(2A) 
      receptor antagonist, or rolipram, a selective PDE-4 inhibitor, failed to 
      reproduce a caffeine-like effect on MDMA-induced dopamine release. These results 
      suggest that caffeine regulates MDMA-induced dopamine release in striatal tissue 
      slices, via inhibition of adenosine A(1) receptors.
CI  - Copyright (c) 2010 Elsevier B.V. All rights reserved.
FAU - Vanattou-Saifoudine, Natacha
AU  - Vanattou-Saifoudine N
AD  - School of Pharmacy and Pharmaceutical Sciences & Trinity College Institute of 
      Neuroscience, Trinity College, Dublin 2, Ireland.
FAU - Gossen, Anna
AU  - Gossen A
FAU - Harkin, Andrew
AU  - Harkin A
CN  - Neuropsychopharmacology Research Group
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101014
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Adenosine A1 Receptor Antagonists)
RN  - 0 (Receptor, Adenosine A1)
RN  - 0 (Xanthines)
RN  - 3G6A5W338E (Caffeine)
RN  - 9PTP4FOI9E (1,3-dipropyl-8-cyclopentylxanthine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Adenosine A1 Receptor Antagonists/*pharmacology
MH  - Animals
MH  - Caffeine/*pharmacology
MH  - Dopamine/*metabolism
MH  - Dose-Response Relationship, Drug
MH  - Drug Synergism
MH  - Hypothalamus/drug effects/metabolism
MH  - In Vitro Techniques
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Neostriatum/*drug effects/*metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptor, Adenosine A1/*metabolism
MH  - Xanthines/pharmacology
EDAT- 2010/10/19 06:00
MHDA- 2011/03/25 06:00
CRDT- 2010/10/19 06:00
PHST- 2010/07/01 00:00 [received]
PHST- 2010/09/10 00:00 [revised]
PHST- 2010/10/03 00:00 [accepted]
PHST- 2010/10/19 06:00 [entrez]
PHST- 2010/10/19 06:00 [pubmed]
PHST- 2011/03/25 06:00 [medline]
AID - S0014-2999(10)01015-0 [pii]
AID - 10.1016/j.ejphar.2010.10.012 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 2011 Jan 10;650(1):220-8. doi: 10.1016/j.ejphar.2010.10.012. 
      Epub 2010 Oct 14.