PMID- 20952062
OWN - NLM
STAT- MEDLINE
DCOM- 20110309
LR  - 20110125
IS  - 1873-5835 (Electronic)
IS  - 0145-2126 (Linking)
VI  - 35
IP  - 2
DP  - 2011 Feb
TI  - Cryptic IGH/BCL2 rearrangements with variant FISH patterns in follicular 
      lymphoma.
PG  - 256-9
LID - 10.1016/j.leukres.2010.09.011 [doi]
AB  - Follicular lymphoma (FL) is one of the most common non-Hodgkin lymphomas (NHL). 
      Translocation t(14;18)(q32;q21) involving IGH and BCL2 genes represents its 
      genetic hallmark. We present six cases of a series of 75 well diagnosed FL 
      patients in which variant fluorescence in situ hybridization (FISH) patterns for 
      this rearrangement were found. Moreover, G-banding cytogenetics and polymerase 
      chain reaction (PCR) methods were unable to detect t(14;18)(q32;q21). According 
      to our results, FISH is the best technique to define variant rearrangements of 
      IGH/BCL2 genes and is important to detect it in cases with non-conclusive FL 
      characteristics to avoid misdiagnosis with other NHL.
CI  - Copyright (c) 2010 Elsevier Ltd. All rights reserved.
FAU - Baro, Cristina
AU  - Baro C
AD  - Laboratori de Citogenetica Molecular, Servei de Patologia, Hospital del Mar, Parc 
      de Salut Mar, GRETNHE, IMIM-Hospital del Mar, Barcelona, Spain.
FAU - Espinet, Blanca
AU  - Espinet B
FAU - Salido, Marta
AU  - Salido M
FAU - Garcia, Mar
AU  - Garcia M
FAU - Sanchez, Blanca
AU  - Sanchez B
FAU - Florensa, Lourdes
AU  - Florensa L
FAU - Bellosillo, Beatriz
AU  - Bellosillo B
FAU - Serrano, Sergi
AU  - Serrano S
FAU - Sole, Francesc
AU  - Sole F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101016
PL  - England
TA  - Leuk Res
JT  - Leukemia research
JID - 7706787
SB  - IM
MH  - Chromosome Aberrations
MH  - Chromosomes, Human, Pair 14/genetics
MH  - Chromosomes, Human, Pair 18/genetics
MH  - Genes, Immunoglobulin Heavy Chain/*genetics
MH  - Genes, bcl-2/*genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Lymphoma, Follicular/*genetics
MH  - Polymerase Chain Reaction
MH  - Translocation, Genetic/*genetics
EDAT- 2010/10/19 06:00
MHDA- 2011/03/10 06:00
CRDT- 2010/10/19 06:00
PHST- 2009/11/30 00:00 [received]
PHST- 2010/07/16 00:00 [revised]
PHST- 2010/09/16 00:00 [accepted]
PHST- 2010/10/19 06:00 [entrez]
PHST- 2010/10/19 06:00 [pubmed]
PHST- 2011/03/10 06:00 [medline]
AID - S0145-2126(10)00459-5 [pii]
AID - 10.1016/j.leukres.2010.09.011 [doi]
PST - ppublish
SO  - Leuk Res. 2011 Feb;35(2):256-9. doi: 10.1016/j.leukres.2010.09.011. Epub 2010 Oct 
      16.