PMID- 20952227
OWN - NLM
STAT- MEDLINE
DCOM- 20110330
LR  - 20181201
IS  - 1528-395X (Electronic)
IS  - 1079-2104 (Linking)
VI  - 110
IP  - 6
DP  - 2010 Dec
TI  - Up-regulation of EGF receptor and its ligands, AREG, EREG, and HB-EGF in oral 
      lichen planus.
PG  - 748-54
LID - 10.1016/j.tripleo.2010.06.022 [doi]
AB  - OBJECTIVE: This study aimed to investigate the roles of the epidermal growth 
      factor receptor (EGFR) family members and their ligands in oral lichen planus 
      (OLP). STUDY DESIGN: The expressions of 4 EGFR-like receptors and 6 EGF-like 
      ligands were measured in OLP tissues from 10 patients and compared with the 
      levels in normal oral mucosa (NOM) from 10 healthy donors. RESULTS: Of the 
      receptors, only EGFR mRNA and protein were more highly expressed in OLP compared 
      with NOM tissues. Regarding the ligands, the mRNAs of amphiregulin (AREG), 
      epiregulin (EREG), and heparin-binding EGF-like growth factor (HB-EGF) were more 
      highly expressed in OLP compared with NOM tissues. These ligands were strongly 
      expressed by infiltrating lamina propria lymphocytes as well as epithelial 
      keratinocytes in OLP lesions, as shown by immunohistochemistry. CONCLUSIONS: The 
      enhanced EGFR expression on the keratinocytes in OLP lesions and the 
      up-regulation of EGF-like ligands in keratinocytes and infiltrating mononuclear 
      cells could contribute to the carcinogenesis and pathogenesis of OLP.
CI  - Copyright (c) 2010 Mosby, Inc. All rights reserved.
FAU - Kumagai, Kenichi
AU  - Kumagai K
AD  - Department of Oral and Maxillofacial Surgery, Tsurumi University, Tsurumi-ku, 
      Yokohama, Japan.
FAU - Horikawa, Tatsuya
AU  - Horikawa T
FAU - Gotoh, Akito
AU  - Gotoh A
FAU - Yamane, Shoji
AU  - Yamane S
FAU - Yamada, Hiroyuki
AU  - Yamada H
FAU - Kobayashi, Hiroshi
AU  - Kobayashi H
FAU - Hamada, Yoshiki
AU  - Hamada Y
FAU - Suzuki, Satsuki
AU  - Suzuki S
FAU - Suzuki, Ryuji
AU  - Suzuki R
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101016
PL  - United States
TA  - Oral Surg Oral Med Oral Pathol Oral Radiol Endod
JT  - Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
JID - 9508562
RN  - 0 (AREG protein, human)
RN  - 0 (Amphiregulin)
RN  - 0 (BTC protein, human)
RN  - 0 (Betacellulin)
RN  - 0 (CD3 Complex)
RN  - 0 (EGF Family of Proteins)
RN  - 0 (EREG protein, human)
RN  - 0 (Epiregulin)
RN  - 0 (Glycoproteins)
RN  - 0 (HBEGF protein, human)
RN  - 0 (Heparin-binding EGF-like Growth Factor)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Transforming Growth Factor alpha)
RN  - 62229-50-9 (Epidermal Growth Factor)
RN  - 9005-49-6 (Heparin)
RN  - EC 2.7.10.1 (ERBB4 protein, human)
RN  - EC 2.7.10.1 (ErbB Receptors)
RN  - EC 2.7.10.1 (Receptor, ErbB-2)
RN  - EC 2.7.10.1 (Receptor, ErbB-3)
RN  - EC 2.7.10.1 (Receptor, ErbB-4)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Amphiregulin
MH  - Betacellulin
MH  - CD3 Complex/analysis
MH  - EGF Family of Proteins
MH  - Epidermal Growth Factor/*analysis
MH  - Epiregulin
MH  - Epithelial Cells/pathology
MH  - ErbB Receptors/*analysis
MH  - Female
MH  - Glycoproteins/*analysis
MH  - Heparin/*analysis
MH  - Heparin-binding EGF-like Growth Factor
MH  - Humans
MH  - Immunohistochemistry
MH  - Intercellular Signaling Peptides and Proteins/*analysis
MH  - Keratinocytes/pathology
MH  - Leukocytes, Mononuclear/pathology
MH  - Lichen Planus, Oral/*pathology
MH  - Lymphocytes/pathology
MH  - Male
MH  - Middle Aged
MH  - Mouth Mucosa/pathology
MH  - Polymerase Chain Reaction/methods
MH  - Receptor, ErbB-2/analysis
MH  - Receptor, ErbB-3/analysis
MH  - Receptor, ErbB-4
MH  - Receptors, Cell Surface/*analysis
MH  - T-Lymphocytes/pathology
MH  - Transforming Growth Factor alpha/analysis
MH  - Up-Regulation/*genetics
EDAT- 2010/10/19 06:00
MHDA- 2011/03/31 06:00
CRDT- 2010/10/19 06:00
PHST- 2009/11/03 00:00 [received]
PHST- 2010/06/23 00:00 [revised]
PHST- 2010/06/25 00:00 [accepted]
PHST- 2010/10/19 06:00 [entrez]
PHST- 2010/10/19 06:00 [pubmed]
PHST- 2011/03/31 06:00 [medline]
AID - S1079-2104(10)00495-6 [pii]
AID - 10.1016/j.tripleo.2010.06.022 [doi]
PST - ppublish
SO  - Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010 Dec;110(6):748-54. doi: 
      10.1016/j.tripleo.2010.06.022. Epub 2010 Oct 16.