PMID- 20952768
OWN - NLM
STAT- MEDLINE
DCOM- 20110623
LR  - 20211020
IS  - 1879-0844 (Electronic)
IS  - 1388-9842 (Print)
IS  - 1388-9842 (Linking)
VI  - 13
IP  - 3
DP  - 2011 Mar
TI  - Influence of cardiomegaly on disordered breathing during exercise in chronic 
      heart failure.
PG  - 311-8
LID - 10.1093/eurjhf/hfq177 [doi]
AB  - AIMS: Heart failure (HF) patients breathe with a rapid shallow pattern during 
      exercise. This study examined the relationship between cardiac size and 
      tachypnoeic breathing in HF patients during exercise. METHODS AND RESULTS: 
      Thirty-seven HF patients [age = 55 +/- 13 years, ejection fraction (EF) = 27 +/- 10%, 
      New York Heart Association (NYHA) class = 2.3 +/- 1.2] and 42 controls (CTL) (age = 
      56 +/- 14 years, EF = 63 +/- 8%) were recruited. Participants underwent maximal 
      exercise testing, pulmonary function testing, and chest radiography for 
      calculation of total thoracic cavity volume (TTCV), diaphragm, heart, and lung 
      volumes. Heart failure patients were divided into two groups: Group A = cardiac 
      volume < median (n = 18) and Group B = cardiac volume >/= median of the HF patients 
      (n = 19). There was no difference between groups for TTCV (CTL = 8203 +/- 1489 vs. 
      Group A = 8694 +/- 1249 vs. Group B = 8195 +/- 1823 cm(3)). Cardiac volume was 
      different between groups for both absolute (CTL = 630 +/- 181 vs. Group A = 894 +/- 
      186 vs. Group B = 1401 +/- 382 cm(3), P< 0.001 for all comparisons) and %TTCV (CTL 
      = 8 +/- 2 vs. Group A = 10 +/- 1 vs. Group A = 18 +/- 5%, P< 0.001 for all 
      comparisons). Similarly, total lung volume as a %TTCV was significantly different 
      among the groups (CTL = 70 +/- 4 vs. Group A = 65 +/- 5 vs. Group A = 58 +/- 7%, P< 
      0.01 for all comparisons). In HF patients, there was a trend (P = 0.10) towards 
      an independent association between cardiac size and tidal volume (V(T)) at 75% of 
      VO(2) peak whereas this relationship was statistically significant at VO(2) peak 
      (P = 0.02) as patients with larger cardiac size had reduced V(T). CONCLUSION: 
      This study demonstrates the close relationship between cardiac size and breathing 
      pattern during exercise in HF patients. These results suggest cardiac size may 
      pose a significant constraint on the lungs during exercise and may contribute to 
      tachypnoeic breathing.
FAU - Olson, Thomas P
AU  - Olson TP
AD  - Division of Cardiovascular Diseases, Department of Internal Medicine, Joseph 
      4-221, Mayo Clinic and Foundation, Rochester, MN 55905, USA. 
      olson.thomas2@mayo.edu
FAU - Johnson, Bruce D
AU  - Johnson BD
LA  - eng
GR  - 1KL2RR024151/RR/NCRR NIH HHS/United States
GR  - HL71478/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20101016
PL  - England
TA  - Eur J Heart Fail
JT  - European journal of heart failure
JID - 100887595
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cardiomegaly/complications/physiopathology
MH  - Case-Control Studies
MH  - Chronic Disease
MH  - Exercise/*physiology
MH  - Exercise Test
MH  - Female
MH  - Heart Failure/complications/*physiopathology
MH  - Humans
MH  - Linear Models
MH  - Male
MH  - Middle Aged
MH  - *Respiration
MH  - Respiratory Function Tests
PMC - PMC3041466
EDAT- 2010/10/19 06:00
MHDA- 2011/06/24 06:00
PMCR- 2012/03/01
CRDT- 2010/10/19 06:00
PHST- 2010/10/19 06:00 [entrez]
PHST- 2010/10/19 06:00 [pubmed]
PHST- 2011/06/24 06:00 [medline]
PHST- 2012/03/01 00:00 [pmc-release]
AID - hfq177 [pii]
AID - 10.1093/eurjhf/hfq177 [doi]
PST - ppublish
SO  - Eur J Heart Fail. 2011 Mar;13(3):311-8. doi: 10.1093/eurjhf/hfq177. Epub 2010 Oct 
      16.