PMID- 20954233
OWN - NLM
STAT- MEDLINE
DCOM- 20110609
LR  - 20161018
IS  - 1552-8618 (Electronic)
IS  - 0730-7268 (Linking)
VI  - 29
IP  - 12
DP  - 2010 Dec
TI  - Developmental triclosan exposure decreases maternal and neonatal thyroxine in 
      rats.
PG  - 2840-4
LID - 10.1002/etc.339 [doi]
AB  - Disruption of maternal thyroid hormones during fetal developmental may result in 
      irreversible neurological consequences in offspring. The present study tested the 
      hypothesis that perinatal triclosan exposure of dams decreases thyroxine in dams 
      and offspring prior to weaning. Pregnant Long-Evans rats received triclosan by 
      oral gavage (0-300 mg/kg/d) in corn oil from gestational day (GD)6 through 
      postnatal day (PND)21. Serum was obtained from pups on PND4, 14, and 21, and from 
      dams on PND22. Serum thyroxine (T4) was reduced 31% in dams on PND22. In pups, a 
      unique pattern of hypothyroxinemia was observed; serum T4 decreased 27% in PND4 
      pups with no significant reduction observed on PND14 or PND21. Comparable 
      reductions of approximately 30% in serum T4 at 300 mg/kg/d for dams and PND4 
      neonates and a lack of effect at PND14 and PND21 suggest that toxicokinetic or 
      toxicodynamic factors may have contributed to a reduced exposure or a reduced 
      toxicological response during the lactation period.
CI  - Copyright (c) 2010 SETAC.
FAU - Paul, Katie B
AU  - Paul KB
AD  - University of North Carolina, Chapel Hill, North Carolina, USA.
FAU - Hedge, Joan M
AU  - Hedge JM
FAU - Devito, Michael J
AU  - Devito MJ
FAU - Crofton, Kevin M
AU  - Crofton KM
LA  - eng
GR  - T32-ES07126/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20101015
PL  - United States
TA  - Environ Toxicol Chem
JT  - Environmental toxicology and chemistry
JID - 8308958
RN  - 4NM5039Y5X (Triclosan)
RN  - Q51BO43MG4 (Thyroxine)
SB  - IM
MH  - Animals
MH  - Female
MH  - Humans
MH  - Models, Animal
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Rats
MH  - Rats, Long-Evans
MH  - Thyroxine/*blood
MH  - Triclosan/*pharmacology
EDAT- 2010/10/19 06:00
MHDA- 2011/06/10 06:00
CRDT- 2010/10/19 06:00
PHST- 2010/07/20 00:00 [received]
PHST- 2010/08/02 00:00 [revised]
PHST- 2010/08/05 00:00 [accepted]
PHST- 2010/10/19 06:00 [entrez]
PHST- 2010/10/19 06:00 [pubmed]
PHST- 2011/06/10 06:00 [medline]
AID - 10.1002/etc.339 [doi]
PST - ppublish
SO  - Environ Toxicol Chem. 2010 Dec;29(12):2840-4. doi: 10.1002/etc.339. Epub 2010 Oct 
      15.