PMID- 20956642
OWN - NLM
STAT- MEDLINE
DCOM- 20101102
LR  - 20131121
IS  - 1538-3652 (Electronic)
IS  - 0003-987X (Linking)
VI  - 146
IP  - 10
DP  - 2010 Oct
TI  - Subacute cutaneous lupus erythematosus exacerbated or induced by chemotherapy.
PG  - 1113-6
LID - 10.1001/archdermatol.2010.258 [doi]
AB  - BACKGROUND: Subacute cutaneous lupus erythematosus (SCLE), characterized by 
      nonscarring, photodistributed, annular or papulosquamous plaques, is occasionally 
      induced by medication. It has been strongly associated with antihypertensive 
      medications and terbinafine hydrochloride. OBSERVATION: We describe 3 women with 
      breast cancer who developed SCLE-like eruptions after being administered 
      doxorubicin hydrochloride and cyclophosphamide. Biopsy specimens of all 3 
      patients demonstrated an interface dermatitis. Treatment consisted of topical 
      and/or systemic corticosteroids, photoprotection, and switching the 
      chemotherapeutic regimens. CONCLUSIONS: Based on clinicopathologic correlation 
      and timing of chemotherapy exposure, the patients were believed to have 
      drug-induced SCLE. Although cutaneous eruption, pruritus, and photosensitivity 
      are known adverse effects of doxorubicin, to our knowledge there has been only 1 
      previously reported case of doxorubicin-induced SCLE.
FAU - Funke, Alisa A
AU  - Funke AA
AD  - Division of Dermatology, Department of Medicine, University of Louisville School 
      of Medicine, Louisville, Kentucky, USA. alisa.funke@ucdenver.edu
FAU - Kulp-Shorten, Carol L
AU  - Kulp-Shorten CL
FAU - Callen, Jeffrey P
AU  - Callen JP
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Arch Dermatol
JT  - Archives of dermatology
JID - 0372433
RN  - 0 (Antineoplastic Agents)
RN  - 80168379AG (Doxorubicin)
RN  - 8N3DW7272P (Cyclophosphamide)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antineoplastic Agents/*adverse effects
MH  - Cyclophosphamide/*adverse effects
MH  - Doxorubicin/*adverse effects
MH  - Female
MH  - Humans
MH  - Lupus Erythematosus, Cutaneous/*chemically induced
EDAT- 2010/10/20 06:00
MHDA- 2010/11/03 06:00
CRDT- 2010/10/20 06:00
PHST- 2010/10/20 06:00 [entrez]
PHST- 2010/10/20 06:00 [pubmed]
PHST- 2010/11/03 06:00 [medline]
AID - 146/10/1113 [pii]
AID - 10.1001/archdermatol.2010.258 [doi]
PST - ppublish
SO  - Arch Dermatol. 2010 Oct;146(10):1113-6. doi: 10.1001/archdermatol.2010.258.