PMID- 20957479
OWN - NLM
STAT- MEDLINE
DCOM- 20110324
LR  - 20211020
IS  - 1432-1971 (Electronic)
IS  - 0172-0643 (Linking)
VI  - 31
IP  - 8
DP  - 2010 Nov
TI  - Peak circulatory power as an indicator of clinical status in children after 
      Fontan procedure.
PG  - 1203-8
LID - 10.1007/s00246-010-9799-1 [doi]
AB  - Peak circulatory power (CircP), a product of peak exercise oxygen uptake (VO(2)) 
      and peak mean or systolic arterial blood pressure, has proved to be a strong 
      predictor of poor outcome in adults with congenital heart disease. This study 
      sought to compare CircP with other cardiopulmonary exercise (CPX) test variables 
      and to assess whether CircP is superior in categorizing patients into 
      well-functioning vs. poorly functioning at-risk groups in the pediatric 
      population after a Fontan procedure. The CPX test reports of 50 patients were 
      retrospectively reviewed after the Fontan procedure. The patients were divided 
      into two groups. The well-functioning group included patients in New York Heart 
      Association (NYHA) classes 1 and 2 (n = 36). The poorly functioning at-risk group 
      included patients in NYHA classes 3 and 4 and those with significant indicators 
      or outcomes of a poor prognosis (n = 14). The patients in the well-functioning 
      group had significantly higher CircP values based on mean blood pressure (MBP) 
      (P < 0.001), higher CircP values based on systolic blood pressure (SBP) 
      (P < 0.001), and higher peak VO(2) (P = 0.004) than those in the poorly 
      functioning at-risk group. At a cutoff value less than 2100.4 mmHg/mlO(2)/kg/min, 
      CircP MBP had a sensitivity of 85% in categorizing children to the poorly 
      functioning at-risk group. CircP correlated well with the clinical status of our 
      patients. CircP and peak VO(2) did not differ significantly in ability to 
      identify poorly functioning patients. Further prospective analysis is needed to 
      assess whether CircP can serve as a prognostic marker for the pediatric 
      population after Fontan procedure.
FAU - Madan, Nitin
AU  - Madan N
AD  - Department of Pediatrics, The Children's Hospital, Cleveland Clinic Foundation, 
      Cleveland, OH 44195, USA.
FAU - Beachler, Lisa
AU  - Beachler L
FAU - Konstantinopoulos, Pantelis
AU  - Konstantinopoulos P
FAU - Worley, Sarah
AU  - Worley S
FAU - Sun, Zhiyuan
AU  - Sun Z
FAU - Latson, Larry A
AU  - Latson LA
LA  - eng
PT  - Journal Article
DEP - 20101019
PL  - United States
TA  - Pediatr Cardiol
JT  - Pediatric cardiology
JID - 8003849
SB  - IM
MH  - Adolescent
MH  - Blood Pressure/*physiology
MH  - Chi-Square Distribution
MH  - Child
MH  - Cross-Sectional Studies
MH  - Electrocardiography
MH  - *Exercise Test
MH  - Female
MH  - *Fontan Procedure
MH  - Heart Defects, Congenital/*physiopathology/*surgery
MH  - Heart Rate/physiology
MH  - Humans
MH  - Male
MH  - Oxygen Consumption/*physiology
MH  - Prognosis
MH  - ROC Curve
MH  - Retrospective Studies
EDAT- 2010/10/20 06:00
MHDA- 2011/03/25 06:00
CRDT- 2010/10/20 06:00
PHST- 2010/05/26 00:00 [received]
PHST- 2010/09/18 00:00 [accepted]
PHST- 2010/10/20 06:00 [entrez]
PHST- 2010/10/20 06:00 [pubmed]
PHST- 2011/03/25 06:00 [medline]
AID - 10.1007/s00246-010-9799-1 [doi]
PST - ppublish
SO  - Pediatr Cardiol. 2010 Nov;31(8):1203-8. doi: 10.1007/s00246-010-9799-1. Epub 2010 
      Oct 19.