PMID- 20957499
OWN - NLM
STAT- MEDLINE
DCOM- 20110315
LR  - 20211020
IS  - 1435-5922 (Electronic)
IS  - 0944-1174 (Linking)
VI  - 46 Suppl 1
DP  - 2011 Jan
TI  - Genetic background of autoimmune hepatitis in Japan.
PG  - 42-7
LID - 10.1007/s00535-010-0333-2 [doi]
AB  - Autoimmune hepatitis (AIH) is an organ-specific autoimmune disease characterized 
      by chronic inflammation of the liver. Several studies from ethnically different 
      countries have clarified that the genetic predisposition to type 1 AIH is linked 
      mainly to human leukocyte antigen (HLA)-class II genes. Recently, molecular 
      analysis using polymerase chain reaction (PCR)-based DNA typing has revealed that 
      susceptibility to type 1 AIH is primarily associated with the HLA class II DRB1 
      locus, which encodes a polymorphic beta chain of the HLA-DR antigen. However, 
      additional susceptibility genes (either HLA or non-HLA) and/or environmental 
      factors may also contribute to the development of type 1 AIH; in Japanese type 1 
      AIH patients, although the most influential gene in disease susceptibility is 
      HLA-DRB1*04:05, several other genes have been identified as being involved in AIH 
      pathogenesis or resistance and are the currently the focus of single nucleotide 
      polymorphism analysis.
FAU - Yoshizawa, Kaname
AU  - Yoshizawa K
AD  - Department of Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, 
      Matsumoto, 390-8621, Japan. kanamey@shinshu-u.ac.jp
FAU - Umemura, Takeji
AU  - Umemura T
FAU - Ota, Masao
AU  - Ota M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101019
PL  - Japan
TA  - J Gastroenterol
JT  - Journal of gastroenterology
JID - 9430794
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - *Genetic Predisposition to Disease
MH  - HLA-DR Antigens/*immunology
MH  - HLA-DRB1 Chains
MH  - Hepatitis, Autoimmune/epidemiology/*genetics
MH  - Humans
MH  - Japan/epidemiology
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Single Nucleotide
MH  - Tumor Necrosis Factor-alpha/genetics
EDAT- 2010/10/20 06:00
MHDA- 2011/03/16 06:00
CRDT- 2010/10/20 06:00
PHST- 2010/06/28 00:00 [received]
PHST- 2010/09/15 00:00 [accepted]
PHST- 2010/10/20 06:00 [entrez]
PHST- 2010/10/20 06:00 [pubmed]
PHST- 2011/03/16 06:00 [medline]
AID - 10.1007/s00535-010-0333-2 [doi]
PST - ppublish
SO  - J Gastroenterol. 2011 Jan;46 Suppl 1:42-7. doi: 10.1007/s00535-010-0333-2. Epub 
      2010 Oct 19.