PMID- 20960176
OWN - NLM
STAT- MEDLINE
DCOM- 20110324
LR  - 20211020
IS  - 1559-0100 (Electronic)
IS  - 1355-008X (Linking)
VI  - 37
IP  - 3
DP  - 2010 Jun
TI  - Monocyte chemoattractant protein-1 (MCP-1) 2518G/A gene polymorphism in Turkish 
      type 2 diabetes patients with nephropathy.
PG  - 513-7
LID - 10.1007/s12020-010-9342-4 [doi]
AB  - Tissue macrophage accumulation is thought to induce insulin resistance during 
      obesity and stimulate the progression of diabetic nephropathy (DN). The objective 
      of this study was to investigate genotypic and allelic frequencies of monocyte 
      chemoattractant protein-1 (MCP-1) gene polymorphism in the healthy and patients 
      with and without DN. The MCP-1 genotypes were determined in 43 patients with 
      nephropathy and 43 without nephropathy and a control group of 105 healthy 
      individuals. The genotype MCP-1 (-2518G/A) distribution did differ between the 
      control group and the type 2 diabetic patients (P = 0.004). The frequency of the 
      polymorphic G allele was also no similar for the group with type 2 diabetes as 
      for the control group with 20.9 and 32.4%, respectively (P = 0.012). The AA 
      genotype and A allele at MCP-1 -2518 was an independent risk factor for the 
      progression of type 2 diabetes. In conclusion, MCP-1 AA genotype and A allele may 
      play a specific role(s) in determining diabetic susceptibility, but do not seem 
      to be important in the clinical manifestations of DN.
FAU - Karadeniz, M
AU  - Karadeniz M
AD  - Department of Endocrinology and Metabolism Disease, Bornova, Ege University 
      Medical School, Izmir 35100, Turkey. muammerkaradenis@gmail.com
FAU - Erdogan, M
AU  - Erdogan M
FAU - Cetinkalp, Sevki
AU  - Cetinkalp S
FAU - Berdeli, A
AU  - Berdeli A
FAU - Eroglu, Z
AU  - Eroglu Z
FAU - Ozgen, A G
AU  - Ozgen AG
LA  - eng
PT  - Journal Article
DEP - 20100421
PL  - United States
TA  - Endocrine
JT  - Endocrine
JID - 9434444
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Chemokine CCL2/*genetics
MH  - Diabetes Mellitus, Type 2/*genetics
MH  - Diabetic Nephropathies/*genetics
MH  - Humans
MH  - Insulin Resistance/genetics
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
MH  - Turkey
EDAT- 2010/10/21 06:00
MHDA- 2011/03/25 06:00
CRDT- 2010/10/21 06:00
PHST- 2010/01/04 00:00 [received]
PHST- 2010/04/08 00:00 [accepted]
PHST- 2010/10/21 06:00 [entrez]
PHST- 2010/10/21 06:00 [pubmed]
PHST- 2011/03/25 06:00 [medline]
AID - 10.1007/s12020-010-9342-4 [doi]
PST - ppublish
SO  - Endocrine. 2010 Jun;37(3):513-7. doi: 10.1007/s12020-010-9342-4. Epub 2010 Apr 
      21.