PMID- 20961841
OWN - NLM
STAT- MEDLINE
DCOM- 20110407
LR  - 20110805
IS  - 1522-6662 (Electronic)
IS  - 1098-3511 (Linking)
VI  - 13
IP  - 5
DP  - 2010 Oct
TI  - Detection of human herpesvirus 6 DNA but not human herpesvirus 7 or 8 DNA in 
      atherosclerotic and nonatherosclerotic vascular tissues.
PG  - E345-9
LID - 10.1532/HSF98.20101023 [doi]
AB  - INTRODUCTION: Various viral infections are thought to play a role in the 
      development of atherosclerosis. A number of studies suggest that certain viruses 
      from the Herpesviridae family in particular may lead to atherosclerosis. METHODS: 
      We investigated the presence of human herpesvirus 6 (HHV-6), human herpesvirus 7 
      (HHV-7), and human herpesvirus 8 (HHV-8) DNA in carotid, iliac, and coronary 
      artery specimens obtained from a group of adult autopsy cases by means of 
      polymerase chain reaction (PCR) analysis and nested PCR techniques. A 28-subject 
      study group with at least type IV atherosclerosis and a 25-subject control group 
      with no visible atherosclerosis were enrolled. RESULTS: HHV-6 DNA was found in 
      the carotid artery specimen of 1 subject with atherosclerosis, in an iliac artery 
      specimen of another subject, and in the iliac artery specimen of one of the 
      control subjects. HHV-7 or HHV-8 DNA was not found in either the atherosclerosis 
      or control cases. CONCLUSIONS: This study is the first to demonstrate the 
      presence of HHV-6 in atherosclerotic vascular tissues. HHV-7 and HHV-8 were not 
      found in atherosclerotic tissues; however, further research on broader study 
      groups and with different protocols is needed to determine whether these viruses 
      play a role in the formation of atherosclerosis.
FAU - Kaklikkaya, Islam
AU  - Kaklikkaya I
AD  - Department of Cardiovascular Surgery, Karadeniz Technical University, Trabzon, 
      Turkey. ikaklikkaya@yahoo.com
FAU - Kaklikkaya, Nese
AU  - Kaklikkaya N
FAU - Birincioglu, Ismail
AU  - Birincioglu I
FAU - Buruk, Kurtulus
AU  - Buruk K
FAU - Turan, Nursen
AU  - Turan N
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Heart Surg Forum
JT  - The heart surgery forum
JID - 100891112
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Aged
MH  - Atherosclerosis/pathology/*virology
MH  - Cadaver
MH  - Carotid Arteries/*virology
MH  - Coronary Vessels/*virology
MH  - DNA, Viral/*analysis
MH  - Female
MH  - Herpesviridae Infections/virology
MH  - Herpesvirus 6, Human/*genetics
MH  - Herpesvirus 7, Human/genetics
MH  - Herpesvirus 8, Human/genetics
MH  - Humans
MH  - Iliac Artery/*virology
MH  - Male
MH  - Middle Aged
MH  - Polymerase Chain Reaction
MH  - Retrospective Studies
MH  - Roseolovirus Infections/pathology/*virology
EDAT- 2010/10/22 06:00
MHDA- 2011/04/08 06:00
CRDT- 2010/10/22 06:00
PHST- 2010/10/22 06:00 [entrez]
PHST- 2010/10/22 06:00 [pubmed]
PHST- 2011/04/08 06:00 [medline]
AID - H613786470140R43 [pii]
AID - 10.1532/HSF98.20101023 [doi]
PST - ppublish
SO  - Heart Surg Forum. 2010 Oct;13(5):E345-9. doi: 10.1532/HSF98.20101023.