PMID- 20962102
OWN - NLM
STAT- MEDLINE
DCOM- 20110613
LR  - 20110217
IS  - 1755-3245 (Electronic)
IS  - 0008-6363 (Linking)
VI  - 89
IP  - 4
DP  - 2011 Mar 1
TI  - The role of pulmonary veins vs. autonomic ganglia in different experimental 
      substrates of canine atrial fibrillation.
PG  - 825-33
LID - 10.1093/cvr/cvq332 [doi]
AB  - AIMS: Pulmonary vein (PV)-encircling ablation, which is effective in suppressing 
      atrial fibrillation (AF), damages autonomic ganglia near the PV ostia. This study 
      examined the effects of PV isolation (PVI) vs. peri-PV ganglionic plexus ablation 
      (GPA) in two discrete canine AF models: ventricular tachypacing (240 bpm, 2 
      weeks)-induced congestive heart failure (CHF), and atrial tachypacing (400 bpm, 1 
      week)-induced atrial tachycardia remodeling (ATR). METHODS AND RESULTS: All PVs 
      were isolated with an epicardial radiofrequency clamp in nine CHF and eight ATR 
      dogs. Peri-PV ganglionic plexi (identified by bradycardic responses to 
      high-frequency stimulation) were ablated in six CHF and five ATR dogs with an 
      epicardial radiofrequency-ablation pen. Electrophysiologic measurements, 
      including 240-electrode AF mapping, were obtained and dominant frequencies (DFs) 
      determined. Atrial growth associated protein-43 (GAP-43) and neurofilament-M 
      (NF-M) expression were determined immunohistologically. In CHF, neither PVI nor 
      GPA affected AF duration, DF or the already low AF vulnerability. In ATR, PVI 
      reduced AF vulnerability (75 +/- 6% to 55 +/- 11%, P< 0.05) but did not alter AF 
      duration or DF. In contrast, GPA prolonged atrial refractory period and decreased 
      AF vulnerability (75 +/- 8 to 30 +/- 10%, P< 0.05), AF duration (617 +/- 246 to 39 +/- 23 
      s, **P< 0.01), and DF (11.4 +/- 0.6 to 8.6 +/- 0.3** Hz, left atrium) in ATR dogs. 
      Both GAP-43 and NF-M expression were decreased in CHF (by 63.1** and 60.0%**) and 
      increased in ATR (by 65.5** and 92.1%, P< 0.001) compared with control. 
      CONCLUSIONS: PVs play a minor role in experimental AF due to CHF or ATR, but 
      autonomic ganglia are important in AF related to ATR. Differential neural 
      remodelling may contribute to varying effects of GPA in discrete AF substrates.
FAU - Nishida, Kunihiro
AU  - Nishida K
AD  - Research Center and Department of Medicine, Montreal Heart Institute and 
      Universite de Montreal, 5000 Belanger Street, Montreal, QC, Canada H1T 1C8.
FAU - Maguy, Ange
AU  - Maguy A
FAU - Sakabe, Masao
AU  - Sakabe M
FAU - Comtois, Philippe
AU  - Comtois P
FAU - Inoue, Hiroshi
AU  - Inoue H
FAU - Nattel, Stanley
AU  - Nattel S
LA  - eng
GR  - MGP 6957/Canadian Institutes of Health Research/Canada
GR  - MOP44365/Canadian Institutes of Health Research/Canada
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101020
PL  - England
TA  - Cardiovasc Res
JT  - Cardiovascular research
JID - 0077427
SB  - IM
MH  - Animals
MH  - Atrial Fibrillation/*etiology/physiopathology
MH  - Dogs
MH  - Ganglia, Autonomic/*physiology
MH  - Heart Failure/complications/pathology/physiopathology
MH  - Pulmonary Veins/*physiology
MH  - Refractory Period, Electrophysiological
MH  - Tachycardia/complications
EDAT- 2010/10/22 06:00
MHDA- 2011/06/15 06:00
CRDT- 2010/10/22 06:00
PHST- 2010/10/22 06:00 [entrez]
PHST- 2010/10/22 06:00 [pubmed]
PHST- 2011/06/15 06:00 [medline]
AID - cvq332 [pii]
AID - 10.1093/cvr/cvq332 [doi]
PST - ppublish
SO  - Cardiovasc Res. 2011 Mar 1;89(4):825-33. doi: 10.1093/cvr/cvq332. Epub 2010 Oct 
      20.