PMID- 20962454
OWN - NLM
STAT- MEDLINE
DCOM- 20110224
LR  - 20190911
IS  - 1347-8648 (Electronic)
IS  - 1347-8613 (Linking)
VI  - 114
IP  - 2
DP  - 2010
TI  - Neuroprotective effects of genistein in Mongolian gerbils: estrogen receptor-beta 
      involvement.
PG  - 158-67
AB  - Genistein is a naturally occurring plant-derived phytoestrogen, present in the 
      human diet, known to possess some beneficial effects. The present study 
      investigated the effect of genistein on neuroprotection evaluated through 
      electroencephalographic and behavioural correlates in a model of global cerebral 
      ischemia in gerbils. Over the dose range tested, genistein (3 and 10 mg/kg), 
      given 5 min after recirculation antagonized the ischemia-induced 
      electroencephalographic total spectral power decrease 7 days after ischemia; 
      fully prevented ischemia-induced hyperlocomotion evaluated 1 day after ischemia; 
      reversed ischemia-induced memory impairment evaluated through both nest building 
      behaviour and object recognition test; decreased malondialdehyde overproduction 
      in the brain, evaluated 7 days after reperfusion; and fully promoted the survival 
      of pyramidal cells in the CA(1) hippocampal subfield. The selective antagonist 
      for estrogen receptor-beta (ERbeta), 4-[2-phenyl-5,7-bis(trifluoromethyl) 
      pyrazolo[1,5-a]pyrimidin-3-yl]phenol (PHTPP) given 30 min before carotid 
      occlusion, fully prevented the neuroprotective effect of genistein at the dose of 
      3 mg/kg. These results demonstrate the neuroprotective effect of genistein 
      through the activation of ERbeta and provide further grounds for the growing 
      interest concerning the true potential of phytoestrogens as compounds to 
      beneficially affect brain injury without having the disadvantages of estrogens.
FAU - Donzelli, Andrea
AU  - Donzelli A
AD  - Department of Pharmacology, Chemotherapy and Medical Toxicology, Universita degli 
      Studi di Milano, Italy.
FAU - Braida, Daniela
AU  - Braida D
FAU - Finardi, Annamaria
AU  - Finardi A
FAU - Capurro, Valeria
AU  - Capurro V
FAU - Valsecchi, Anna Elisa
AU  - Valsecchi AE
FAU - Colleoni, Mariapia
AU  - Colleoni M
FAU - Sala, Mariaelvina
AU  - Sala M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - J Pharmacol Sci
JT  - Journal of pharmacological sciences
JID - 101167001
RN  - 0 (Estrogen Receptor beta)
RN  - 0 (Neuroprotective Agents)
RN  - DH2M523P0H (Genistein)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/drug effects
MH  - Brain/drug effects/physiopathology
MH  - Brain Ischemia/physiopathology
MH  - Disease Models, Animal
MH  - Dose-Response Relationship, Drug
MH  - Electroencephalography/drug effects
MH  - Estrogen Receptor beta/*metabolism
MH  - Genistein/*pharmacology
MH  - Gerbillinae
MH  - Hippocampus/drug effects/physiopathology
MH  - Male
MH  - Neuroprotective Agents/*pharmacology
MH  - Pyramidal Cells/drug effects/physiopathology
EDAT- 2010/10/22 06:00
MHDA- 2011/02/25 06:00
CRDT- 2010/10/22 06:00
PHST- 2010/10/22 06:00 [entrez]
PHST- 2010/10/22 06:00 [pubmed]
PHST- 2011/02/25 06:00 [medline]
AID - JST.JSTAGE/jphs/10164FP [pii]
AID - 10.1254/jphs.10164fp [doi]
PST - ppublish
SO  - J Pharmacol Sci. 2010;114(2):158-67. doi: 10.1254/jphs.10164fp.