PMID- 20962626
OWN - NLM
STAT- MEDLINE
DCOM- 20110601
LR  - 20101223
IS  - 1473-5733 (Electronic)
IS  - 0957-5235 (Linking)
VI  - 22
IP  - 1
DP  - 2011 Jan
TI  - Association between the monocyte chemoattractant protein-1 -2518G/A gene 
      polymorphism and acute myocardial infarction patients among Egyptian population.
PG  - 7-13
LID - 10.1097/MBC.0b013e328340126c [doi]
AB  - The aim of the present study was to investigate the possible association between 
      the -2518G/A polymorphism of the monocyte chemoattractant protein-1 (MCP-1) gene 
      and acute myocardial infarction (MI) in a sample of the Egyptian population. A 
      total of 30 Egyptian patients with coronary artery disease (CAD) manifested as 
      acute myocardial infarction (MI) for the first time and 25 unrelated healthy 
      control individuals were genotyped by polymerase chain reaction-restriction 
      fragment length polymorphism (PCR-RFLP). The proportion of G/A and G/G genotypes 
      were significantly higher in the acute MI group than the control group (P < 
      0.05). The acute MI patients group showed a significant higher frequency of the G 
      allele compared to the controls (P < 0.05). Analysis of the relationship between 
      the G/A, G/G genotypes and A/A genotype acute MI group regarding the conventional 
      risk factors showed statistical significant difference regarding age, total 
      cholesterol, low-density lipoprotein and high-density lipoprotein (P < 0.05), but 
      there was no significant relationship regarding sex, smoking, history of diabetes 
      mellitus, hypertension, obesity, body mass index (BMI) and triglyceride, but we 
      observed that the percentage of men was higher than the percentage of women in 
      both G/A, G/G genotypes and A/A genotype acute MI patients. Also, among our 
      patients, the percentage of smokers, diabetics, hypertensive, and obesity and the 
      mean of BMI and triglyceride were higher in the G/A, G/G genotypes acute MI 
      patients than that in A/A genotype acute MI patients. In conclusion, our study 
      indicated that there was a significant association between the MCP-1 -2518G/A 
      polymorphism and acute MI in the Egyptian population, but this significant 
      association is dependent on the presence of MI risk factors.
FAU - El Mahgoub, Iman R
AU  - El Mahgoub IR
AD  - Department of Clinical & Chemical Pathology, Faculty of Medicine, Cairo 
      University, Egypt.
FAU - Afify, Reham A
AU  - Afify RA
FAU - Aal, Asmaa A Abdel
AU  - Aal AA
FAU - Beda, Dalia G
AU  - Beda DG
LA  - eng
PT  - Journal Article
PL  - England
TA  - Blood Coagul Fibrinolysis
JT  - Blood coagulation & fibrinolysis : an international journal in haemostasis and 
      thrombosis
JID - 9102551
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Chemokine CCL2/*genetics
MH  - Egypt/epidemiology
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/epidemiology/*genetics
MH  - *Polymorphism, Genetic
MH  - Risk Factors
EDAT- 2010/10/22 06:00
MHDA- 2011/06/02 06:00
CRDT- 2010/10/22 06:00
PHST- 2010/10/22 06:00 [entrez]
PHST- 2010/10/22 06:00 [pubmed]
PHST- 2011/06/02 06:00 [medline]
AID - 10.1097/MBC.0b013e328340126c [doi]
PST - ppublish
SO  - Blood Coagul Fibrinolysis. 2011 Jan;22(1):7-13. doi: 
      10.1097/MBC.0b013e328340126c.