PMID- 20963443
OWN - NLM
STAT- MEDLINE
DCOM- 20110809
LR  - 20211020
IS  - 1432-1084 (Electronic)
IS  - 0938-7994 (Linking)
VI  - 21
IP  - 5
DP  - 2011 May
TI  - Cardiac magnetic resonance imaging in dilated cardiomyopathy in adults--towards 
      identification of myocardial inflammation.
PG  - 925-35
LID - 10.1007/s00330-010-1985-2 [doi]
AB  - OBJECTIVE: To assess active myocardial inflammation by cardiovascular magnetic 
      resonance (CMR) and endomyocardial biopsy (EMB) amongst adult patients with 
      dilated cardiomyopathy (DCM). METHODS: We evaluated 23 adults with chronic DCM, 
      who had successfully undergone both CMR and EMB within 3.5 +/- 2.6 days. EMB was 
      considered the gold standard. CMR assessment of myocardial inflammation used the 
      following parameters as recommended by the recently published "Lake Louise 
      Criteria": global myocardial oedema, global relative enhancement (RE), and late 
      gadolinium enhancement (LGE). According to "Lake Louise Criteria", myocardial 
      inflammation was diagnosed if two or more of the three above-mentioned parameters 
      were positive. RESULTS: Myocardial inflammation was confirmed by immunohistology 
      in 12 patients (52.2%). Sensitivity, specificity, and diagnostic accuracy of CMR 
      to detect immunohistologically confirmed myocardial inflammation were 75.0%, 
      72.7%, and 73.9%, respectively. Sensitivity, specificity, and diagnostic accuracy 
      of the individual CMR parameters to detect myocardial inflammation were as 
      follows: global myocardial oedema, 91.7%, 81.8%, and 87.0%, respectively; global 
      RE, 58.3%, 63.6%, and 60.9%, respectively; LGE, 58.3%, 45.4%, and 52.2%, 
      respectively. CONCLUSION: Global myocardial oedema was identified as a promising 
      CMR parameter for assessment of myocardial inflammation in patients with DCM. In 
      these patients, global myocardial oedema yielded superior diagnostic performance 
      compared to "Lake Louise Criteria".
FAU - Voigt, Antje
AU  - Voigt A
AD  - Department of Cardiology, Campus Mitte, Charite-Universitatsmedizin Berlin, 10117 
      Berlin, Germany.
FAU - Elgeti, Thomas
AU  - Elgeti T
FAU - Durmus, Tahir
AU  - Durmus T
FAU - Idiz, Merve Ece
AU  - Idiz ME
FAU - Butler, Craig
AU  - Butler C
FAU - Beling, Mark
AU  - Beling M
FAU - Schilling, Rene
AU  - Schilling R
FAU - Klingel, Karin
AU  - Klingel K
FAU - Kandolf, Reinhard
AU  - Kandolf R
FAU - Stangl, Karl
AU  - Stangl K
FAU - Taupitz, Matthias
AU  - Taupitz M
FAU - Kivelitz, Dietmar
AU  - Kivelitz D
FAU - Wagner, Moritz
AU  - Wagner M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101021
PL  - Germany
TA  - Eur Radiol
JT  - European radiology
JID - 9114774
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
MH  - Adult
MH  - Biopsy
MH  - Cardiomyopathy, Dilated/*pathology
MH  - Echocardiography/methods
MH  - Edema/pathology
MH  - Female
MH  - Gadolinium/pharmacology
MH  - Humans
MH  - Inflammation
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Myocarditis/*pathology
MH  - Myocardium/*pathology
MH  - Retrospective Studies
MH  - Sensitivity and Specificity
EDAT- 2010/10/22 06:00
MHDA- 2011/08/10 06:00
CRDT- 2010/10/22 06:00
PHST- 2010/05/26 00:00 [received]
PHST- 2010/09/10 00:00 [accepted]
PHST- 2010/08/30 00:00 [revised]
PHST- 2010/10/22 06:00 [entrez]
PHST- 2010/10/22 06:00 [pubmed]
PHST- 2011/08/10 06:00 [medline]
AID - 10.1007/s00330-010-1985-2 [doi]
PST - ppublish
SO  - Eur Radiol. 2011 May;21(5):925-35. doi: 10.1007/s00330-010-1985-2. Epub 2010 Oct 
      21.