PMID- 20963503
OWN - NLM
STAT- MEDLINE
DCOM- 20110523
LR  - 20221207
IS  - 1573-4978 (Electronic)
IS  - 0301-4851 (Linking)
VI  - 38
IP  - 3
DP  - 2011 Mar
TI  - Relationship between surfactant protein A polymorphisms and allergic rhinitis in 
      a Chinese Han population.
PG  - 1475-82
LID - 10.1007/s11033-010-0254-4 [doi]
AB  - The development of allergic rhinitis is considered to be determined by the 
      interaction between genetic and environmental factors. Surfactant protein A 
      (SP-A), a member of the collectin family of proteins, plays an important role in 
      immune regulation. The purpose of this study was to investigate the association 
      between SP-A polymorphisms and allergic rhinitis. We conducted a case-control 
      association study on a Chinese Han population, comprising 216 adult individuals 
      with AR and 84 healthy controls. A total of 9 single-nucleotide polymorphisms 
      (SNPs) mapped to the SP-A were genotyped using PCR-based molecular identification 
      methods. The frequency of A allele at amino acid 223 in the patient group was 
      significantly higher than that in the control group after correcting for multiple 
      testing (P = 0.006). The 1A(2) allele haplotype in SFTPA2 was associated with 
      decreased risk for allergic rhinitis, after applying Bonferroni corrections (P = 
      0.003). However, genetic variants of the SFTPA1 genes were not found to be 
      associated with AR. In addition, no significant associations were established 
      between any of the 9 SFTPA gene polymorphisms and the skin-prick test responses 
      (P > 0.05). Further, no association was established between the 9 SNP loci and 
      the levels of total serum immunoglobulin E (IgE) (P > 0.05). These results 
      indicate that the gene polymorphism at the residue 223 in the carbohydrate 
      recognition domain of SFTPA2 may be a genetic marker for the development of AR in 
      the adult Chinese Han population.
FAU - Deng, Yuqin
AU  - Deng Y
AD  - Department of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan 
      University, Wuhan 430060, China.
FAU - Chen, Shiming
AU  - Chen S
FAU - Chen, Jinhui
AU  - Chen J
FAU - Tao, Zezhang
AU  - Tao Z
FAU - Kong, Yonggang
AU  - Kong Y
FAU - Xu, Yu
AU  - Xu Y
FAU - Xiao, Bokui
AU  - Xiao B
FAU - He, Qing
AU  - He Q
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101021
PL  - Netherlands
TA  - Mol Biol Rep
JT  - Molecular biology reports
JID - 0403234
RN  - 0 (Pulmonary Surfactant-Associated Protein A)
RN  - 0 (SFTPA1 protein, human)
RN  - 0 (SFTPA2 protein, human)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Asian People/*genetics
MH  - Case-Control Studies
MH  - Ethnicity/*genetics
MH  - Genetic Association Studies
MH  - *Genetic Predisposition to Disease
MH  - Haplotypes/genetics
MH  - Humans
MH  - Linkage Disequilibrium/genetics
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide
MH  - Pulmonary Surfactant-Associated Protein A/*genetics
MH  - Rhinitis, Allergic, Perennial/*genetics
MH  - Young Adult
EDAT- 2010/10/22 06:00
MHDA- 2011/05/24 06:00
CRDT- 2010/10/22 06:00
PHST- 2009/11/24 00:00 [received]
PHST- 2010/09/02 00:00 [accepted]
PHST- 2010/10/22 06:00 [entrez]
PHST- 2010/10/22 06:00 [pubmed]
PHST- 2011/05/24 06:00 [medline]
AID - 10.1007/s11033-010-0254-4 [doi]
PST - ppublish
SO  - Mol Biol Rep. 2011 Mar;38(3):1475-82. doi: 10.1007/s11033-010-0254-4. Epub 2010 
      Oct 21.