PMID- 20964950
OWN - NLM
STAT- MEDLINE
DCOM- 20111101
LR  - 20220310
IS  - 1539-6304 (Electronic)
IS  - 1088-5412 (Linking)
VI  - 31
IP  - 6
DP  - 2010 Nov-Dec
TI  - The burden of hospitalizations and emergency department visits with hereditary 
      angioedema and angioedema in the United States, 2007.
PG  - 511-9
LID - 10.2500/aap.2010.31.3403 [doi]
AB  - Hereditary angioedema (HAE) is a rare inherited disorder of complement factor C1 
      inhibitor. HAE is frequently confused with angioedema (AE), and little is known 
      about emergency department (ED) or hospital utilization by patients with attacks 
      in the United States. We examined hospitalizations and ED utilization for HAE and 
      AE in two large nationally representative databases. We evaluated annual rate and 
      resource use of HAE (International Classification of Diseases, Version 9, 
      Clinical Modification [ICD-9-CM] code 277.6) and AE (ICD-9-CM code 995.1) 
      hospitalizations within Nationwide Inpatient Sample (NIS), part of the Agency of 
      Healthcare Research and Quality's Healthcare Costs and Utilization Project 
      (AHRQ-HCUP), for 2007. We also used AHRQ-HCUP's 2007 Nationwide Emergency 
      Department Sample (NEDS) to study annual rates of ED visits and subsequent 
      hospitalizations with these conditions. There were 1691 hospitalizations with HAE 
      and 22,572 with AE (4.25 HAE and 57.08 AE cases/100,000 hospitalizations). HAE 
      was the principal diagnosis (PD) in 46.0% and AE in 62.5%. In aggregate, HAE and 
      AE PD hospitalizations accrued 35,000 hospital days and hospital costs of $63 
      million. There were 2282 ED visits with HAE and 112,105 ED visits with AE (1.87 
      HAE and 91.64 AE cases/100,000 ED visits). HAE occurred as a PD in 51.2% and AE 
      occurred as a PD in 80.0%. Forty-five percent of HAE patients and 18.3% of AE 
      patients required hospitalization. HAE and AE ED use and hospitalization burden 
      are substantial. Because diagnostic uncertainty is likely, HAE-related proportion 
      of patients and resource use are probably underestimated. Clinical validation of 
      current case definition would be useful, because administrative data may present 
      an attractive source for investigating these populations.
FAU - Zilberberg, Marya D
AU  - Zilberberg MD
AD  - Department of Public Health, School of Public Health and Health Sciences, 
      University of Massachusetts, Amherst, Massachusetts, USA. evimedgroup@gmail.com
FAU - Jacobsen, Thomas
AU  - Jacobsen T
FAU - Tillotson, Glenn
AU  - Tillotson G
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101020
PL  - United States
TA  - Allergy Asthma Proc
JT  - Allergy and asthma proceedings
JID - 9603640
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Angioedemas, Hereditary/diagnosis/*economics/*epidemiology/physiopathology
MH  - Databases as Topic
MH  - Disease Progression
MH  - Emergency Medical Services/*statistics & numerical data
MH  - Female
MH  - *Health Care Costs
MH  - Hospitalization/*statistics & numerical data
MH  - Humans
MH  - International Classification of Diseases
MH  - Male
MH  - Middle Aged
MH  - United States
EDAT- 2010/10/23 06:00
MHDA- 2011/11/02 06:00
CRDT- 2010/10/23 06:00
PHST- 2010/10/23 06:00 [entrez]
PHST- 2010/10/23 06:00 [pubmed]
PHST- 2011/11/02 06:00 [medline]
AID - 3403 [pii]
AID - 10.2500/aap.2010.31.3403 [doi]
PST - ppublish
SO  - Allergy Asthma Proc. 2010 Nov-Dec;31(6):511-9. doi: 10.2500/aap.2010.31.3403. 
      Epub 2010 Oct 20.