PMID- 20966461
OWN - NLM
STAT- MEDLINE
DCOM- 20110426
LR  - 20101223
IS  - 1460-2350 (Electronic)
IS  - 0268-1161 (Linking)
VI  - 26
IP  - 1
DP  - 2011 Jan
TI  - ESHRE PGD consortium best practice guidelines for fluorescence in situ 
      hybridization-based PGD.
PG  - 25-32
LID - 10.1093/humrep/deq230 [doi]
AB  - In 2005, the European Society for Human Reproduction and Embryology (ESHRE) PGD 
      Consortium published a set of Guidelines for Best Practice PGD to give 
      information, support and guidance to potential, existing and fledgling PGD 
      programmes. The subsequent years have seen the introduction of new technologies 
      as well as evolution of current techniques. Additionally, in light of recent 
      advice from ESHRE on how practice guidelines should be written and formulated, 
      the Consortium believed it was timely to revise and update the PGD guidelines. 
      Rather than one document that covers all of PGD, the new guidelines are separated 
      into four new documents that apply to different aspects of a PGD programme, i.e. 
      organization of a PGD centre, fluorescence in situ hybridization (FISH)-based 
      testing, amplification-based testing and polar body and embryo biopsy for 
      PGD/preimplantation genetic screening (PGS). Here, we have updated the sections 
      that pertain to FISH-based PGD. PGS has become a highly controversial technique. 
      Opinions of laboratory specialists and clinicians interested in PGD and PGS have 
      been taken into account here. Whereas some believe that PGS does not have a place 
      in clinical medicine, others disagree; therefore, PGS has been included. This 
      document should assist everyone interested in PGD/PGS in developing the best 
      laboratory and clinical practice possible. Topics covered in this guideline 
      include inclusion/exclusion criteria for FISH-based PGD testing, referrals and 
      genetic counselling, preclinical validation of tests, FISH-based testing methods, 
      spreading of cells for analysis, set-up of local IVF centre and transport PGD 
      centres, quality control/ quality assurance and diagnostic confirmation of 
      untransferred embryos.
FAU - Harton, G L
AU  - Harton GL
AD  - Reprogenetics LLC, Livingston, NJ 07039, USA. gharton@reprogenetics.com
FAU - Harper, J C
AU  - Harper JC
FAU - Coonen, E
AU  - Coonen E
FAU - Pehlivan, T
AU  - Pehlivan T
FAU - Vesela, K
AU  - Vesela K
FAU - Wilton, L
AU  - Wilton L
CN  - European Society for Human Reproduction and Embryology (ESHRE) PGD Consortium
LA  - eng
PT  - Journal Article
PT  - Practice Guideline
DEP - 20101021
PL  - England
TA  - Hum Reprod
JT  - Human reproduction (Oxford, England)
JID - 8701199
SB  - IM
MH  - Blastocyst
MH  - Chromosome Aberrations
MH  - Chromosome Disorders/*diagnosis
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/*methods
MH  - Preimplantation Diagnosis/*methods
MH  - Quality Control
MH  - Sex Determination Analysis
MH  - Specimen Handling/standards
EDAT- 2010/10/23 06:00
MHDA- 2011/04/27 06:00
CRDT- 2010/10/23 06:00
PHST- 2010/10/23 06:00 [entrez]
PHST- 2010/10/23 06:00 [pubmed]
PHST- 2011/04/27 06:00 [medline]
AID - deq230 [pii]
AID - 10.1093/humrep/deq230 [doi]
PST - ppublish
SO  - Hum Reprod. 2011 Jan;26(1):25-32. doi: 10.1093/humrep/deq230. Epub 2010 Oct 21.