PMID- 20969657
OWN - NLM
STAT- MEDLINE
DCOM- 20101130
LR  - 20101025
IS  - 1524-4725 (Electronic)
IS  - 1076-0512 (Linking)
VI  - 36 Suppl 3
DP  - 2010 Nov
TI  - Improvement in nasolabial folds with a hyaluronic acid filler using a cohesive 
      polydensified matrix technology: results from an 18-month open-label extension 
      trial.
PG  - 1800-8
LID - 10.1111/j.1524-4725.2010.01735.x [doi]
AB  - BACKGROUND: Repeat treatments of nonpermanent dermal fillers are used in the 
      long-term treatment of wrinkles and folds and to volumize. OBJECTIVE To determine 
      the safety and effectiveness of a nonanimal-sourced hyaluronic acid (HA) (which 
      uses a cohesive polydensified matrix (CPM) technology [CPMHA]) for the treatment 
      of nasolabial folds (NLFs) during an 18-month open-label extension trial. METHODS 
      AND MATERIALS: Ninety-five of 118 subjects continued with this optional 
      open-label extension of a split-face, double-blind trial. All subjects received 
      CPMHA in both NLFs at 24 weeks after treatment in this study and were assessed at 
      weeks 32, 48, 72, and 96. Touch-ups were allowed for optimal correction. Safety 
      was assessed according to reported adverse events (AEs) and serum antibody 
      measurement. RESULTS: At all four post-week 24 time points, the severity of the 
      NLFs showed a decrease from baseline on the Wrinkle Severity Rating Scale. The 
      effects persisted in the majority ( approximately 80%) of subjects without repeat treatment for 
      at least one interval of 48 weeks. The study filler was well tolerated, with only 
      one related AE (injection site bruising) reported. Little potential for 
      immunogenic reactions was identified. CONCLUSION: This CPMHA is a well-tolerated 
      and effective treatment for at least 48 weeks in the majority of subjects for the 
      correction of moderate to severe NLFs with repeat injections given over an 
      18-month period.
CI  - (c) 2010 by the American Society for Dermatologic Surgery, Inc.
FAU - Narins, Rhoda S
AU  - Narins RS
AD  - Dermatology Surgery and Laser Center, White Plains, New York 10604, USA. 
      rsnmd@worldnet.att.net
FAU - Coleman, William P 3rd
AU  - Coleman WP 3rd
FAU - Donofrio, Lisa M
AU  - Donofrio LM
FAU - Jones, Derek H
AU  - Jones DH
FAU - Maas, Corey
AU  - Maas C
FAU - Monheit, Gary
AU  - Monheit G
FAU - Kaur, Mandeep
AU  - Kaur M
FAU - Grundy, Starr L
AU  - Grundy SL
FAU - Pappert, Eric J
AU  - Pappert EJ
FAU - Hardas, Bhushan
AU  - Hardas B
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Dermatol Surg
JT  - Dermatologic surgery : official publication for American Society for Dermatologic 
      Surgery [et al.]
JID - 9504371
RN  - 0 (Viscosupplements)
RN  - 9004-61-9 (Hyaluronic Acid)
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Cosmetic Techniques
MH  - Double-Blind Method
MH  - Face
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Hyaluronic Acid/*administration & dosage
MH  - Injections, Intradermal/methods
MH  - Male
MH  - Middle Aged
MH  - Patient Satisfaction
MH  - Rhytidoplasty/*methods
MH  - *Skin Aging
MH  - Time Factors
MH  - Treatment Outcome
MH  - Viscosupplements/*administration & dosage
EDAT- 2010/11/05 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/10/26 06:00
PHST- 2010/10/26 06:00 [entrez]
PHST- 2010/11/05 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 10.1111/j.1524-4725.2010.01735.x [doi]
PST - ppublish
SO  - Dermatol Surg. 2010 Nov;36 Suppl 3:1800-8. doi: 10.1111/j.1524-4725.2010.01735.x.