PMID- 20969970
OWN - NLM
STAT- MEDLINE
DCOM- 20110913
LR  - 20211020
IS  - 1523-6536 (Electronic)
IS  - 1083-8791 (Print)
IS  - 1083-8791 (Linking)
VI  - 17
IP  - 6
DP  - 2011 Jun
TI  - Outcomes of patients with myeloid malignancies treated with allogeneic 
      hematopoietic stem cell transplantation from matched unrelated donors compared 
      with one human leukocyte antigen mismatched related donors using HLA typing at 10 
      loci.
PG  - 923-9
LID - 10.1016/j.bbmt.2010.10.017 [doi]
AB  - Most candidates for hematopoietic stem cell transplantation (HSCT) lack a human 
      leukocyte antigen (HLA)-identical sibling donor. Some patients may have a related 
      donor with whom they are mismatched at 1 antigen/allele. It is not known whether 
      such a match is preferable to a matched unrelated donor (MUD). We evaluated the 
      outcomes (survival, relapse, nonrelapse mortality [NRM]) of all 28 patients with 
      a single HLA antigen/allele mismatch identified through high-resolution HLA 
      typing at HLA-A, -B, -C, -DRB1, and -DQB1, and all 318 patients with myeloid 
      malignancies who received transplants from a 10/10 MUD treated during the same 
      period of time at a single institution. Overall, outcomes for patients treated 
      from a 1-antigen/allele mismatch related donor were significantly worse than from 
      a MUD, primarily because of increased NRM. Overall survival (OS) rates at 3 years 
      for 1-antigen/allele mismatched related donor and MUD transplant recipients were 
      19% and 45% (P = .007), and NRM rates were 40% and 26% (P = .05), respectively. 
      Patients with class I mismatches appeared to have poorer OS than did patients 
      with class II mismatches. A higher incidence of graft rejection was identified in 
      the mismatched related donor group (P = .02). These results indicate that 
      transplant outcomes are better with a MUD than with a 1 antigen/allele-mismatched 
      related donor.
CI  - Copyright (c) 2011 American Society for Blood and Marrow Transplantation. Published 
      by Elsevier Inc. All rights reserved.
FAU - Ciurea, Stefan O
AU  - Ciurea SO
AD  - Department of Stem Cell Transplantation and Cellular Therapy, The University of 
      Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.
FAU - Saliba, Rima M
AU  - Saliba RM
FAU - Rondon, Gabriela
AU  - Rondon G
FAU - Patah, Poliana A
AU  - Patah PA
FAU - Aung, Fleur
AU  - Aung F
FAU - Cano, Pedro
AU  - Cano P
FAU - Andersson, Borje S
AU  - Andersson BS
FAU - Kebriaei, Partow
AU  - Kebriaei P
FAU - Popat, Uday
AU  - Popat U
FAU - Fernandez-Vina, Marcelo
AU  - Fernandez-Vina M
FAU - Champlin, Richard E
AU  - Champlin RE
FAU - de Lima, Marcos
AU  - de Lima M
LA  - eng
GR  - P30 CA016672/CA/NCI NIH HHS/United States
PT  - Journal Article
DEP - 20101020
PL  - United States
TA  - Biol Blood Marrow Transplant
JT  - Biology of blood and marrow transplantation : journal of the American Society for 
      Blood and Marrow Transplantation
JID - 9600628
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Alleles
MH  - Blood Donors
MH  - Female
MH  - Graft Rejection/immunology/prevention & control
MH  - Graft vs Host Disease/genetics/*immunology/mortality/pathology
MH  - HLA Antigens/genetics/*immunology
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Histocompatibility
MH  - Histocompatibility Testing/*methods
MH  - Humans
MH  - Leukemia, Myeloid/genetics/*immunology/mortality/pathology/*therapy
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Survival Analysis
MH  - Transplantation
MH  - Transplantation, Homologous
MH  - Treatment Outcome
PMC - PMC4112359
MID - NIHMS601820
EDAT- 2010/10/26 06:00
MHDA- 2011/09/14 06:00
PMCR- 2014/07/28
CRDT- 2010/10/26 06:00
PHST- 2010/08/13 00:00 [received]
PHST- 2010/10/13 00:00 [accepted]
PHST- 2010/10/26 06:00 [entrez]
PHST- 2010/10/26 06:00 [pubmed]
PHST- 2011/09/14 06:00 [medline]
PHST- 2014/07/28 00:00 [pmc-release]
AID - S1083-8791(10)00455-6 [pii]
AID - 10.1016/j.bbmt.2010.10.017 [doi]
PST - ppublish
SO  - Biol Blood Marrow Transplant. 2011 Jun;17(6):923-9. doi: 
      10.1016/j.bbmt.2010.10.017. Epub 2010 Oct 20.