PMID- 20969980
OWN - NLM
STAT- MEDLINE
DCOM- 20110331
LR  - 20101221
IS  - 1872-9649 (Electronic)
IS  - 1568-1637 (Linking)
VI  - 10
IP  - 1
DP  - 2011 Jan
TI  - Caloric restriction and longevity: effects of reduced body temperature.
PG  - 153-62
LID - 10.1016/j.arr.2010.10.001 [doi]
AB  - Caloric restriction (CR) causes a reduction in body temperature (T(b)) which is 
      suggested to contribute to changes that increase lifespan. Moreover, low T(b) has 
      been shown to improve health and longevity independent of CR. In this review we 
      examine the connections between CR, T(b) and mechanisms that influence longevity 
      and ageing. Recent findings regarding the overlapping mechanisms of CR and T(b) 
      that benefit longevity are discussed, including changes in body composition, 
      hormone regulation, and gene expression, as well as reductions in low-level 
      inflammation and reactive oxygen species-induced molecular damage. This 
      information is summarized in a model describing how CR and low T(b), both 
      synergistically and independently, increase lifespan. Moreover, the nascent 
      notion that the rate of ageing may be pre-programmed in response to environmental 
      influences at critical periods of early development is also considered. Based on 
      current evidence, it is concluded that low T(b) plays an integral role in 
      mediating the effects of CR on health and longevity, and that low T(b) may exert 
      independent biological changes that increase lifespan. Our understanding of the 
      overlap between CR- and T(b)-mediated longevity remains incomplete and should be 
      explored in future research.
CI  - Copyright (c) 2010 Elsevier B.V. All rights reserved.
FAU - Carrillo, Andres E
AU  - Carrillo AE
AD  - FAME Laboratory, Institute of Human Performance and Rehabilitation, Centre for 
      Research and Technology Thessaly, Trikala, Greece.
FAU - Flouris, Andreas D
AU  - Flouris AD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20101020
PL  - England
TA  - Ageing Res Rev
JT  - Ageing research reviews
JID - 101128963
SB  - IM
MH  - Adaptation, Physiological/physiology
MH  - Adipose Tissue, Brown/physiology
MH  - Animals
MH  - Body Composition/physiology
MH  - Body Temperature/*physiology
MH  - *Caloric Restriction
MH  - Cold Temperature
MH  - Health
MH  - Humans
MH  - Longevity/*physiology
MH  - Oxidative Stress/physiology
EDAT- 2010/10/26 06:00
MHDA- 2011/04/01 06:00
CRDT- 2010/10/26 06:00
PHST- 2010/09/02 00:00 [received]
PHST- 2010/09/27 00:00 [revised]
PHST- 2010/10/01 00:00 [accepted]
PHST- 2010/10/26 06:00 [entrez]
PHST- 2010/10/26 06:00 [pubmed]
PHST- 2011/04/01 06:00 [medline]
AID - S1568-1637(10)00102-9 [pii]
AID - 10.1016/j.arr.2010.10.001 [doi]
PST - ppublish
SO  - Ageing Res Rev. 2011 Jan;10(1):153-62. doi: 10.1016/j.arr.2010.10.001. Epub 2010 
      Oct 20.