PMID- 20970683
OWN - NLM
STAT- MEDLINE
DCOM- 20110328
LR  - 20101025
IS  - 1873-2623 (Electronic)
IS  - 0041-1345 (Linking)
VI  - 42
IP  - 8
DP  - 2010 Oct
TI  - Role of glucocorticoid-induced leucine zipper (GILZ) expression by dendritic 
      cells in tolerance induction.
PG  - 3331-2
LID - 10.1016/j.transproceed.2010.07.038 [doi]
AB  - Dendritic cells (DCs) play a crucial role in T cell allorecognition in the 
      context of organ transplantation and allogeneic hematopoietic stem cell 
      transplantation (allo-HSCT). This DC function is believed to be directly involved 
      in allo-HSCT morbidity and mortality. DC functions range from immunoaggressive 
      responses to the promotion of tolerance, reflecting functional plasticity. This 
      unique characteristic offers a rationale to propose generation of tolerogenic DCs 
      as a therapeutic tool for graft-versus-host disease (GVHD). The accumulated 
      preclinical findings support the concept that glucocorticoid-induced leucine 
      zipper (GLIZ) expression redirects mature DC function toward a tolerogenic mode, 
      driving differentiation of antigen-specific regulatory T cells. Taking into 
      account the unique role of DCs within the allo-HSCT context, novel preventive and 
      curative therapeutics for GVHD might be based on the selective induction of GILZ 
      expression in vivo.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Krzysiek, R
AU  - Krzysiek R
AD  - INSERM U996, Universite Paris-Sud 11 and Hopital Antoine Beclere, Assistance 
      Publique Hopitaux de Paris, Clamart, France. roman.krzysiek@abc.aphp.fr
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
RN  - 0 (TSC22D3 protein, human)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Dendritic Cells/*immunology
MH  - Graft vs Host Disease/prevention & control
MH  - Humans
MH  - *Immune Tolerance
MH  - Transcription Factors/*physiology
EDAT- 2010/10/26 06:00
MHDA- 2011/03/29 06:00
CRDT- 2010/10/26 06:00
PHST- 2010/10/26 06:00 [entrez]
PHST- 2010/10/26 06:00 [pubmed]
PHST- 2011/03/29 06:00 [medline]
AID - S0041-1345(10)01083-3 [pii]
AID - 10.1016/j.transproceed.2010.07.038 [doi]
PST - ppublish
SO  - Transplant Proc. 2010 Oct;42(8):3331-2. doi: 10.1016/j.transproceed.2010.07.038.