PMID- 20971084
OWN - NLM
STAT- MEDLINE
DCOM- 20110630
LR  - 20181201
IS  - 1872-6240 (Electronic)
IS  - 0006-8993 (Linking)
VI  - 1368
DP  - 2011 Jan 12
TI  - Synergistic benefit of combined amlodipine plus atorvastatin on neuronal damage 
      after stroke in Zucker metabolic rat.
PG  - 317-23
LID - 10.1016/j.brainres.2010.10.046 [doi]
AB  - Stroke is a major neurologic disorder and a leading cause of death in the world. 
      We compared neuroprotective effects of single or combination therapy of 
      amlodipine (AM) and atorvastatin (AT) in such a metabolic syndrome model Zucker 
      rat after 90 min of transient middle cerebral artery occlusion (tMCAO). The 
      animals were pretreated with vehicle, AM, AT, or the combination of AM plus AT 
      for 28 days, and at 24h of tMCAO, infarct volume and immunohistochemical analyses 
      were performed. The combination of AM plus AT treatment decreased the infarct 
      volume stronger than each single treatment with AM or AT. The numbers of positive 
      cells of oxidative stress markers such as 8-hydroxy-2'-deoxyguanosin (8-OHdG), 
      4-hydroxy-2-nonenal (4-HNE), and advanced end glycation products (AGE) and 
      inflammation markers such as tumor necrosis factor alpha (TNF-alpha) and monocyte 
      chemoattractant protein-1(MCP-1) decreased dramatically in the 
      combination-treated group compared with single AM- or AT-treated group. The 
      present study showed that single AM or AT treatment showed neuroprotective 
      effects both with antioxidative and anti-inflammatory mechanisms, but combination 
      therapy of AM plus AT presented a further synergistic benefit in acute ischemic 
      neural damages.
CI  - Copyright A(c) 2010 Elsevier B.V. All rights reserved.
FAU - Kawai, Hiromi
AU  - Kawai H
AD  - Department of Neurology, Graduate School of Medicine, Dentistry and 
      pharmaceutical Sciences, Okayama University, 2-5-1 Shikatacho, Okayama 700-8558, 
      Japan.
FAU - Deguchi, Shoko
AU  - Deguchi S
FAU - Deguchi, Kentaro
AU  - Deguchi K
FAU - Yamashita, Toru
AU  - Yamashita T
FAU - Ohta, Yasuyuki
AU  - Ohta Y
FAU - Shang, Jingwei
AU  - Shang J
FAU - Tian, Fengfeng
AU  - Tian F
FAU - Zhang, Xuemei
AU  - Zhang X
FAU - Liu, Ning
AU  - Liu N
FAU - Liu, Wentao
AU  - Liu W
FAU - Ikeda, Yoshio
AU  - Ikeda Y
FAU - Matsuura, Tohru
AU  - Matsuura T
FAU - Abe, Koji
AU  - Abe K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101021
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Anticholesteremic Agents)
RN  - 0 (Calcium Channel Blockers)
RN  - 0 (Heptanoic Acids)
RN  - 0 (Pyrroles)
RN  - 1J444QC288 (Amlodipine)
RN  - A0JWA85V8F (Atorvastatin)
SB  - IM
MH  - Amlodipine/administration & dosage/*pharmacology
MH  - Animals
MH  - Anticholesteremic Agents/administration & dosage/*pharmacology
MH  - Atorvastatin
MH  - Calcium Channel Blockers/administration & dosage/*pharmacology
MH  - Drug Synergism
MH  - Drug Therapy, Combination
MH  - Heptanoic Acids/administration & dosage/*pharmacology
MH  - Male
MH  - Neurons/*pathology
MH  - Pyrroles/administration & dosage/*pharmacology
MH  - Rats
MH  - Rats, Zucker
MH  - Stroke/*pathology
EDAT- 2010/10/26 06:00
MHDA- 2011/07/01 06:00
CRDT- 2010/10/26 06:00
PHST- 2010/09/07 00:00 [received]
PHST- 2010/10/09 00:00 [revised]
PHST- 2010/10/14 00:00 [accepted]
PHST- 2010/10/26 06:00 [entrez]
PHST- 2010/10/26 06:00 [pubmed]
PHST- 2011/07/01 06:00 [medline]
AID - S0006-8993(10)02315-2 [pii]
AID - 10.1016/j.brainres.2010.10.046 [doi]
PST - ppublish
SO  - Brain Res. 2011 Jan 12;1368:317-23. doi: 10.1016/j.brainres.2010.10.046. Epub 
      2010 Oct 21.